Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 7/20 | 0.50 |
| ▸ | TUBB | P07437 | 7/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 7/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 7/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 7/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 7/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 7/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 7/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 7/20 | 0.50 |
| ▸ | TUBA1C | Q9BQE3 | 7/20 | 0.50 |
| ▸ | TUBB6 | Q9BUF5 | 7/20 | 0.50 |
| ▸ | TUBB2B | Q9BVA1 | 7/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4132763 | 0.89 | KDM4E (0.51) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL4121479 | 0.89 | KDM4E (0.51) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL4123012 | 0.89 | KDM4E (0.51) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL17304627 | 0.87 | ALDH1A1 (0.58) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL9324546 | 0.86 | KDM4E (0.53) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL3088172 | 0.84 | KDM4E (0.54) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL16999965 | 0.84 | KDM4E (0.54) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL3967795 | 0.84 | KDM4E (0.54) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL7117998 | 0.84 | KDM4E (0.58) | KDM4EALDH1A1HPGDMEN1MAPT | |
| SCHEMBL17304628 | 0.83 | KDM4E (0.57) | KDM4EALDH1A1HPGDMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633242-B2 | Benzylidene indanones and processes for preparation and use thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2014-01-21 | — | — | US | claimed |
| US-20130079396-A1 | Anticancer and Tubulin Polymerisation Inhibition Activity of Benzylidene Indanones and Process of Preparing the Same | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2013-03-28 | — | — | US | claimed |
| US-20230052517-A1 | ELECTROCHEMICAL SENSING METHODS AND APPARATUS FOR DETERMINING DRUG UPTAKE AND RETENTION IN CELLS | THE UNIVERSITY OF MANITOBA (CA) | 2023-02-16 | — | — | US | disclosed |
| EP-3322687-B1 | 2-BENZYL-INDANONE COMPOUNDS AS ANTICANCER AGENT AND A PROCESS FOR PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2020-02-26 | — | — | EP | disclosed |
| US-8633242-B2 | Benzylidene indanones and processes for preparation and use thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2014-01-21 | — | — | US | disclosed |
| US-8633242-B2 | Benzylidene indanones and processes for preparation and use thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2014-01-21 | — | — | US | disclosed |
| US-20130079396-A1 | Anticancer and Tubulin Polymerisation Inhibition Activity of Benzylidene Indanones and Process of Preparing the Same | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2013-03-28 | — | — | US | disclosed |
| US-20130079396-A1 | Anticancer and Tubulin Polymerisation Inhibition Activity of Benzylidene Indanones and Process of Preparing the Same | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2013-03-28 | — | — | US | disclosed |
| WO-2012068284-A2 | EFFICIENT METHOD FOR PREPARING FUNCTIONALIZED BENZOSUBERENES | BAYLOR UNIVERSITY (US) | 2012-05-24 | — | — | WO | disclosed |
| US-20120130129-A1 | Efficient Method for Preparing Functionalized Benzosuberenes | BAYLOR UNIVERSITY (US) | 2012-05-24 | — | — | US | disclosed |
| US-5318976-A | Topoisomerase inhibitors | GLAXO INC. (US) | 1994-06-07 | — | — | US | disclosed |
| US-5223506-A | CYCLIC ANTITUMOR COMPOUNDS | GLAXO INC. (US) | 1993-06-29 | — | — | US | disclosed |
| WO-1992021661-A1 | CYCLIC ANTITUMOR COMPOUNDS | GLAXO INC. (US) | 1992-12-10 | — | — | WO | disclosed |
| US-4826975-A | HYPOTENSIVE, ANTICOAGULANT, ANTILIPEMIC | MAGGIONI-WINTHROP S.P.A. (IT) | 1989-05-02 | — | — | US | disclosed |
| WO-1987002035-A1 | FUSED CYCLOALIPHATIC AMINOALCOHOLS | MAGGIONI-WINTHROP S.P.A. (IT) | 1987-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130079396-A1 | Anticancer and Tubulin Polymerisation Inhibition Activity of Benzylidene Indanones and Process of Preparing the Same | TUBB6, TUBB, TUBB1 | KDM4E 1892/4885ALDH1A1 826/4885HPGD 1620/4885 |
| US-20120130129-A1 | Efficient Method for Preparing Functionalized Benzosuberenes | CYP2B6, CYP2A6, GABRA6 | KDM4E 232/4885ALDH1A1 1302/4885HPGD 599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.