Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 2/20 | 0.43 |
| ▸ | RHOC | P08134 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | YAP1 | P46937 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.36 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15710272 | 0.87 | STS (0.52) | EPHX2MAPK1HTTSTSCNR1 | |
| SCHEMBL13280057 | 0.87 | RHOA (0.38) | RHOARHOCYAP1NOTUMCXCR3 | |
| SCHEMBL13280371 | 0.86 | YAP1 (0.49) | YAP1NOTUMTSHRCFTR | |
| SCHEMBL18830151 | 0.85 | YAP1 (0.51) | EPHX2YAP1NOTUMTSHRLMNA | |
| SCHEMBL15710931 | 0.85 | TACR1 (0.36) | RHOARHOCYAP1NOTUMCYP2D6 | |
| SCHEMBL27982605 | 0.84 | RHOA (0.36) | RHOARHOCYAP1NOTUMCXCR3 | |
| SCHEMBL13281830 | 0.83 | OPRK1 (0.41) | RHOARHOCYAP1CYP2D6LMNA | |
| SCHEMBL15731225 | 0.83 | MAPK1 (0.41) | EPHX2YAP1NOTUMMAPK1CFTR | |
| SCHEMBL15648246 | 0.83 | OPRK1 (0.43) | YAP1 | |
| SCHEMBL15731226 | 0.79 | NOTUM (0.40) | YAP1NOTUMCYP2D6TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906537-A2 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2015-08-19 | — | — | EP | disclosed |