Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | WNT3A | P56704 | 3/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15549461 | 0.81 | SMN1; SMN2 (0.39) | L3MBTL1LMNANAPRTP4HTMCES2 | |
| SCHEMBL20524441 | 0.81 | LMNA (0.49) | L3MBTL1LMNANAPRTP4HTMCES2 | |
| SCHEMBL27883073 | 0.80 | CES2 (0.48) | L3MBTL1LMNANAPRTP4HTMCES2 | |
| SCHEMBL15658741 | 0.80 | KDM4E (0.45) | LMNANAPRTKMT2AALDH1A1NPC1 | |
| SCHEMBL20237246 | 0.80 | ALDH1A1 (0.48) | L3MBTL1KMT2AALDH1A1NPC1PKM | |
| SCHEMBL15282567 | 0.79 | ALDH1A1 (0.45) | L3MBTL1LMNACES1KMT2AALDH1A1 | |
| SCHEMBL15660113 | 0.78 | SMN1; SMN2 (0.43) | L3MBTL1LMNAP4HTMKMT2AALDH1A1 | |
| SCHEMBL17014180 | 0.78 | CTNNB1 (0.42) | L3MBTL1LMNANAPRTP4HTMCES2 | |
| SCHEMBL11128987 | 0.77 | LMNA (0.45) | L3MBTL1LMNANAPRTP4HTMCES2 | |
| SCHEMBL4555882 | 0.75 | CES2 (0.53) | L3MBTL1LMNANAPRTP4HTMCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2912041-B1 | TETRAHYDROPYRROLOTHIAZINE DERIVATIVES AS BACE INHIBITORS | LILLY CO ELI (US) | 2016-12-14 | — | — | EP | disclosed |
| US-9328124-B2 | BACE inhibitors | ELI LILLY AND COMPANY (US) | 2016-05-03 | — | — | US | disclosed |
| US-20150232483-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY | 2015-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232483-A1 | BACE INHIBITORS | BACE1, BACE2, APP | L3MBTL1 2957/4885LMNA 3047/4885NAPRT 2861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.