SCHEMBL17008019

SCHEMBL17008019

Cc1c(Cl)nc(Cl)c(C(=O)O)c1C

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.53
MAPK1 P28482 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
POLB P06746 1/20 0.38
KMT2A Q03164 1/20 0.37
TSHR P16473 2/20 0.36
HPGD P15428 1/20 0.36
PDE10A Q9Y233 2/20 0.36
DHODH Q02127 6/20 0.36
CYP3A4 P08684 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C8 P10632 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2A6 P11509 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
KEAP1 Q14145 1/20 0.35
NFE2L2 Q16236 1/20 0.35
GPR35 Q9HC97 1/20 0.35
NOTUM Q6P988 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31518421 1.00 ALDH1A1 (0.53) ALDH1A1MAPK1SMN1; SMN2POLBKMT2A
SCHEMBL4424068 0.83 ALDH1A1 (0.50) ALDH1A1MAPK1SMN1; SMN2POLBKMT2A
SCHEMBL30932668 0.81 ALDH1A1 (0.48) ALDH1A1MAPK1SMN1; SMN2POLBKMT2A
SCHEMBL38659069 0.81 ALDH1A1 (0.48) ALDH1A1MAPK1SMN1; SMN2POLBKMT2A
SCHEMBL17008104 0.81 ALDH1A1 (0.48) ALDH1A1MAPK1SMN1; SMN2POLBKMT2A
SCHEMBL2094993 0.81 ALDH1A1 (0.48) ALDH1A1MAPK1SMN1; SMN2POLBKMT2A
SCHEMBL9704587 0.80 POLB (0.55) ALDH1A1MAPK1SMN1; SMN2POLBKMT2A
Hydrochloric Acid SCHEMBL9088762 0.79 ALDH1A1 (0.47) ALDH1A1MAPK1SMN1; SMN2POLBKMT2A
SCHEMBL31440847 0.78 ALDH1A1 (0.53) ALDH1A1MAPK1SMN1; SMN2POLBKMT2A
SCHEMBL9704498 0.78 ALDH1A1 (0.53) ALDH1A1MAPK1SMN1; SMN2POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12552790-B2 Positive modulators of the muscarinic acetylcholine receptor M4 VANDERBILT UNIVERSITY (US) 2026-02-17 US disclosed
US-20260035366-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 UNIV VANDERBILT (US) 2026-02-05 US disclosed
US-12448380-B2 Positive modulators of the muscarinic acetylcholine receptor M4 VANDERBILT UNIVERSITY (US) 2025-10-21 US disclosed
US-12344608-B2 Positive modulators of the muscarinic acetylcholine receptor M4 VANDERBILT UNIVERSITY (US) 2025-07-01 US disclosed
US-20250136600-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 VANDERBILT UNIVERSITY 2025-05-01 US disclosed
US-20250122199-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 VANDERBILT UNIVERSITY 2025-04-17 US disclosed
US-20250122201-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 VANDERBILT UNIVERSITY 2025-04-17 US disclosed
US-20250122198-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 VANDERBILT UNIVERSITY 2025-04-17 US disclosed
US-20250122200-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 VANDERBILT UNIVERSITY 2025-04-17 US disclosed
US-20250011320-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 VANDERBILT UNIVERSITY 2025-01-09 US disclosed
WO-2017112719-A1 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR MERCK SHARP & DOHME CORP. (US) 2017-06-29 WO disclosed
EP-3114129-A1 IMIDAZOPYRIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION VIIV Healthcare UK (No.5) Limited (GB) 2017-01-11 EP disclosed
US-9409922-B2 Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication BRISTOL-MYERS SQUIBB COMPANY (US) 2016-08-09 US disclosed
US-9409922-B2 Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication BRISTOL-MYERS SQUIBB COMPANY (US) 2016-08-09 US disclosed
US-9409922-B2 Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication BRISTOL-MYERS SQUIBB COMPANY (US) 2016-08-09 US disclosed
WO-2015126751-A1 IMIDAZOPYRIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION BRISTOL-MYERS SQUIBB COMPANY (US) 2015-08-27 WO disclosed
WO-2015126751-A1 IMIDAZOPYRIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION BRISTOL-MYERS SQUIBB COMPANY (US) 2015-08-27 WO disclosed
US-20150232480-A1 Imidazopyridine Macrocycles as Inhibitors of Human Immunodeficiency Virus Replication VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) 2015-08-20 US disclosed
US-20150232480-A1 Imidazopyridine Macrocycles as Inhibitors of Human Immunodeficiency Virus Replication VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) 2015-08-20 US disclosed
US-20150232480-A1 Imidazopyridine Macrocycles as Inhibitors of Human Immunodeficiency Virus Replication VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) 2015-08-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250122200-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 CHRM4, CHRM1, CHRM3 ALDH1A1 2993/4885MAPK1 2310/4885SMN1; SMN2 2438/4885
US-12552790-B2 Positive modulators of the muscarinic acetylcholine receptor M4 CHRM4, CHRM1, CHRM5 ALDH1A1 2392/4885MAPK1 1327/4885SMN1; SMN2 1480/4885
US-20250011320-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 CHRM4, CHRM1, CHRM3 ALDH1A1 2993/4885MAPK1 2310/4885SMN1; SMN2 2438/4885
US-20250136600-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 CHRM4, CHRM1, CHRM3 ALDH1A1 2993/4885MAPK1 2310/4885SMN1; SMN2 2438/4885
US-20250122201-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 CHRM4, CHRM1, CHRM3 ALDH1A1 2993/4885MAPK1 2310/4885SMN1; SMN2 2438/4885
US-20150232480-A1 Imidazopyridine Macrocycles as Inhibitors of Human Immunodeficiency Virus Replication EIF2AK2, MAVS, TYMP ALDH1A1 3105/4885MAPK1 967/4885SMN1; SMN2 2620/4885
US-12344608-B2 Positive modulators of the muscarinic acetylcholine receptor M4 CHRM4, CHRM1, CHRM3 ALDH1A1 2993/4885MAPK1 2310/4885SMN1; SMN2 2438/4885
US-20250122198-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 CHRM4, CHRM1, CHRM3 ALDH1A1 2993/4885MAPK1 2310/4885SMN1; SMN2 2438/4885
US-20250122199-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 CHRM4, CHRM1, CHRM3 ALDH1A1 2993/4885MAPK1 2310/4885SMN1; SMN2 2438/4885
US-20260035366-A1 POSITIVE MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 CHRM4, CHRM3, CHRM5 ALDH1A1 3334/4885MAPK1 1431/4885SMN1; SMN2 2746/4885
US-12448380-B2 Positive modulators of the muscarinic acetylcholine receptor M4 CHRM4, CHRM1, CHRM3 ALDH1A1 2993/4885MAPK1 2310/4885SMN1; SMN2 2438/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.