Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.47 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.47 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.47 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1858237 | 0.88 | IDO1 (0.55) | IDO1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL13979616 | 0.84 | F2RL1 (0.68) | PLAAT3PLAAT5PLAAT2PLAAT4HPGD | |
| SCHEMBL17593254 | 0.83 | IDO1 (0.53) | IDO1HPGDCYP11B1CYP11B2TDP1 | |
| SCHEMBL1377057 | 0.82 | PLAAT3 (0.53) | PLAAT3PLAAT5PLAAT2PLAAT4TDP1 | |
| SCHEMBL28142573 | 0.81 | PLAAT3 (0.54) | IDO1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL516422 | 0.81 | IDO1 (0.65) | IDO1HPGDF2RL1CYP11B1CYP11B2 | |
| SCHEMBL7960432 | 0.80 | L3MBTL1 (0.53) | HPGDCYP4A11CYP4F2L3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL16062033 | 0.80 | IDO1 (0.63) | IDO1HPGDF2RL1CYP11B1CYP11B2 | |
| SCHEMBL27431284 | 0.79 | MAPT (0.56) | PLAAT3PLAAT5PLAAT2PLAAT4ALOX5 | |
| SCHEMBL22921868 | 0.79 | TSHR (0.58) | F2RL1CYP4A11CYP4F2KMT2AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180079745-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | INCEPTION SCIENCES, INC. | 2018-03-22 | — | — | US | disclosed |
| US-9862708-B2 | Pyrazolone compounds and uses thereof | TEMPEST THERAPEUTICS, INC. (US) | 2018-01-09 | — | — | US | disclosed |
| US-20170174666-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2017-06-22 | — | — | US | disclosed |
| EP-3105205-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | Inception 2, Inc. (US) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015123133-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | INCEPTION 2, INC. (US) | 2015-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174666-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | PPARA, PPARG, PPARD | IDO1 1073/4885PLAAT3 157/4885PLAAT5 265/4885 |
| US-20180079745-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | PPARA, PPARG, PPARD | IDO1 736/4885PLAAT3 298/4885PLAAT5 539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.