SCHEMBL516422

SCHEMBL516422

COC(=O)CCc1ccc(Br)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.65
CYP11B1 P15538 1/20 0.57
CYP11B2 P19099 1/20 0.57
HPGD P15428 1/20 0.57
MEN1 O00255 2/20 0.53
KMT2A Q03164 2/20 0.53
L3MBTL1 Q9Y468 2/20 0.53
CYP1A2 P05177 1/20 0.53
ATM Q13315 1/20 0.53
CYP4F2 P78329 2/20 0.50
CYP4A11 Q02928 2/20 0.50
FFAR1 O14842 1/20 0.50
FFAR4 Q5NUL3 1/20 0.50
POLB P06746 1/20 0.49
CTDSP1 Q9GZU7 1/20 0.49
F2RL1 P55085 1/20 0.49
ADRB2 P07550 1/20 0.48
ADRB1 P08588 1/20 0.48
TAAR1 Q96RJ0 1/20 0.47
TSHR P16473 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL16062033 0.98 IDO1 (0.63) IDO1CYP11B1CYP11B2HPGDMEN1
SCHEMBL22922181 0.90 CYP4F2 (0.59) IDO1KMT2ACYP4F2CYP4A11POLB
SCHEMBL1858237 0.89 IDO1 (0.55) IDO1CYP11B1CYP11B2HPGDMEN1
SCHEMBL2828491 0.87 FFAR1 (0.71) IDO1MEN1KMT2AFFAR1FFAR4
SCHEMBL17593254 0.87 IDO1 (0.53) IDO1CYP11B1CYP11B2HPGDMEN1
SCHEMBL14680583 0.85 IDO1 (0.52) IDO1CYP11B1CYP11B2HPGDMEN1
SCHEMBL11887474 0.85 IDO1 (0.52) IDO1CYP11B1CYP11B2HPGDMEN1
SCHEMBL8879639 0.85 CYP4F2 (0.50) IDO1CYP11B1CYP11B2KMT2ACYP4F2
SCHEMBL1483117 0.85 CYP4F2 (0.50) IDO1CYP11B1CYP11B2KMT2ACYP4F2
SCHEMBL18455229 0.84 IDO1 (0.51) IDO1CYP11B1CYP11B2HPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 156 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250115561-A1 BIPHENYL-SUBSTITUTED EPITHELIAL SODIUM CHANNEL BLOCKING COMPOUNDS PARION SCIENCES, INC. (US) 2025-04-10 US disclosed
US-20250075079-A1 POLYMERIC FLUOROPHORES, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF PREPARING AND USING THE SAME UNIV NORTH CAROLINA STATE (US) 2025-03-06 US disclosed
US-12209088-B2 Hormone receptor modulators for treating metabolic conditions and disorders ARDELYX, INC. (US) 2025-01-28 US disclosed
EP-4469441-A1 BIPHENYL-SUBSTITUTED EPITHELIAL SODIUM CHANNEL BLOCKING COMPOUNDS Parion Sciences, Inc. (US) 2024-12-04 EP disclosed
US-12139617-B2 Polymeric fluorophores, compositions comprising the same, and methods of preparing and using the same NORTH CAROLINA STATE UNIVERSITY (US) 2024-11-12 US disclosed
WO-2024098361-A1 ARTIFICIAL NUCLEIC ACID MOLECULE 斯微(上海)生物科技股份有限公司 2024-05-16 WO disclosed
CN-111655680-B Hormone receptor modulators for the treatment of metabolic mutations and fibrotic conditions and disorders 阿德利克斯股份有限公司 2024-03-05 CN disclosed
US-20230357214-A1 NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY PHENEX PHARMACEUTICALS AKTIENGESELLSCHAFT (DE) 2023-11-09 US disclosed
US-20230357214-A1 NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY PHENEX PHARMACEUTICALS AKTIENGESELLSCHAFT (DE) 2023-11-09 US disclosed
US-20230348363-A1 COMPOUNDS AND THEIR USE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2023-11-02 US disclosed
US-20090088368-A1 COMPOSITIONS COMPRISING THEM AS PPAR MODULATORS IRM LLC (BM) 2009-04-02 US disclosed
US-20090088368-A1 COMPOSITIONS COMPRISING THEM AS PPAR MODULATORS IRM LLC (BM) 2009-04-02 US disclosed
EP-1979360-A1 COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS IRM LLC (BM) 2008-10-15 EP disclosed
CN-100376242-C 2-aryl-propionic acid and medicine composition containing same DOMPAY CO LTD (IT) 2008-03-26 CN disclosed
US-20080004301-A1 Benzene Compound Having 2 or More Substituents DAIICHI SANKYO COMPANY, LIMITED (JP) 2008-01-03 US disclosed
CN-101094827-A Benzene compound having two or more substituents SANKYO CO (JP) 2007-12-26 CN disclosed
WO-2007089667-A1 COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS IRM LLC (BM) 2007-08-09 WO disclosed
EP-1806332-A1 BENZENE COMPOUND HAVING 2 OR MORE SUBSTITUENTS Daiichi Sankyo Company, Limited (JP) 2007-07-11 EP disclosed
CN-1839114-A Cathepsin cysteine protease inhibitors MERCK FROSST CANADA INC (CA) 2006-09-27 CN disclosed
CN-1612729-A 2-Aryl-propionic acids and pharmaceutical compositions containing them DOMPAY CO LTD (IT) 2005-05-04 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250115561-A1 BIPHENYL-SUBSTITUTED EPITHELIAL SODIUM CHANNEL BLOCKING COMPOUNDS CFTR, SCNN1B, SCNN1G IDO1 3764/4885CYP11B1 354/4885CYP11B2 351/4885
US-12209088-B2 Hormone receptor modulators for treating metabolic conditions and disorders NR1H4, FXR1, GLP1R IDO1 1614/4885CYP11B1 226/4885CYP11B2 370/4885
US-20250075079-A1 POLYMERIC FLUOROPHORES, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF PREPARING AND USING THE SAME CLTB, PAICS, HLCS IDO1 3732/4885CYP11B1 3759/4885CYP11B2 4151/4885
US-20230348363-A1 COMPOUNDS AND THEIR USE RXFP1, RXFP3, RXFP2 IDO1 1175/4885CYP11B1 525/4885CYP11B2 599/4885
US-12139617-B2 Polymeric fluorophores, compositions comprising the same, and methods of preparing and using the same CLTB, PAICS, HLCS IDO1 3732/4885CYP11B1 3759/4885CYP11B2 4151/4885
US-20230357214-A1 NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY NR1H2, NR1H3, NR1H4 IDO1 1007/4885CYP11B1 173/4885CYP11B2 205/4885
US-20090088368-A1 COMPOSITIONS COMPRISING THEM AS PPAR MODULATORS PPARG, PPARA, PPARD IDO1 4548/4885CYP11B1 403/4885CYP11B2 576/4885
US-20080004301-A1 Benzene Compound Having 2 or More Substituents NR1H2, NR1H3, NCOR2 IDO1 1421/4885CYP11B1 71/4885CYP11B2 73/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.