SCHEMBL17009273

SCHEMBL17009273

COc1cccc(CNS(=O)(=O)c2cccs2)c1

nearest known ligand 0.69

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.69
SMN1; SMN2 Q16637 2/20 0.61
CYP19A1 P11511 1/20 0.56
TP53 P04637 2/20 0.54
ALDH1A1 P00352 5/20 0.54
LMNA P02545 2/20 0.54
POLB P06746 2/20 0.54
MEN1 O00255 3/20 0.54
GAA P10253 3/20 0.54
KMT2A Q03164 3/20 0.54
MAPT P10636 1/20 0.53
ALOX15 P16050 1/20 0.53
GFER P55789 1/20 0.53
HSD17B10 Q99714 1/20 0.53
CYP2D6 P10635 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL28203960 0.99 PKM (0.68) PKMSMN1; SMN2CYP19A1TP53ALDH1A1
SCHEMBL28204596 0.85 TP53 (0.64) SMN1; SMN2TP53ALDH1A1LMNAPOLB
SCHEMBL17388717 0.83 PKM (0.61) PKMSMN1; SMN2TP53ALDH1A1LMNA
SCHEMBL7211477 0.78 CYP2D6 (0.66) PKMALDH1A1CYP2D6CYP2C9CYP2C19
SCHEMBL17009188 0.78 CYP19A1 (0.61) CYP19A1TP53ALDH1A1LMNAPOLB
SCHEMBL4662858 0.78 CYP19A1 (0.74) CYP19A1ALDH1A1POLBMEN1GAA
SCHEMBL17009269 0.77 SMN1; SMN2 (0.58) PKMSMN1; SMN2TP53ALDH1A1LMNA
SCHEMBL6122734 0.77 TAS2R14 (0.55) PKMSMN1; SMN2TP53ALDH1A1POLB
SCHEMBL17388718 0.77 PKM (0.60) PKMSMN1; SMN2TP53ALDH1A1LMNA
SCHEMBL6123075 0.77 PKM (0.63) PKMSMN1; SMN2TP53ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107820429-B Novel compositions and methods for immunotherapy comprising small molecule integrin receptor-ligand agonist adjuvants 7山药物有限责任公司 2022-08-16 CN disclosed
CN-107820429-A Include the new compositions and method for immunization therapy of small molecule integrin receptors ligand activator adjuvant 7山利益有限责任公司 2018-03-20 CN disclosed
EP-3104867-A1 COMPOSITIONS AND METHODS TO IMPROVE THE HOMING AND GRAFTING OF HEMATOPOETIC STEM CELLS 7 HILLS INTERESTS, LLC (US) 2016-12-21 EP disclosed
WO-2015123447-A1 COMPOSITIONS AND METHODS TO IMPROVE THE HOMING AND GRAFTING OF HEMATOPOETIC STEM CELLS 7 HILLS PHARMA, LLC (US) 2015-08-20 WO disclosed