Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499913 | 0.78 | KDM4E (0.46) | ALDH1A1MAPTPOLBSMN1; SMN2TDP1 | |
| SCHEMBL5500053 | 0.78 | KDM4E (0.46) | ALDH1A1MAPTPOLBSMN1; SMN2TDP1 | |
| SCHEMBL9774580 | 0.77 | ALDH1A1 (0.46) | ALDH1A1MAPTPOLBSMN1; SMN2TDP1 | |
| SCHEMBL9774519 | 0.77 | ALDH1A1 (0.46) | ALDH1A1MAPTPOLBSMN1; SMN2TDP1 | |
| SCHEMBL28906618 | 0.76 | MAPT (0.45) | ALDH1A1MAPTPOLBSMN1; SMN2TDP1 | |
| SCHEMBL500487 | 0.75 | KDM4E (0.47) | ALDH1A1MAPTPOLBSMN1; SMN2TDP1 | |
| SCHEMBL9774544 | 0.74 | MAPT (0.47) | ALDH1A1MAPTPOLBSMN1; SMN2TDP1 | |
| SCHEMBL12022602 | 0.74 | L3MBTL1 (0.44) | ALDH1A1MAPTPOLBSMN1; SMN2TDP1 | |
| SCHEMBL24662233 | 0.74 | ALDH1A1 (0.38) | ALDH1A1MAPTPOLBSMN1; SMN2TDP1 | |
| SCHEMBL16578236 | 0.74 | MMP1 (0.42) | ALDH1A1MAPTMEN1KMT2ADPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3105219-A1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | Incyte Corporation (US) | 2016-12-21 | — | — | EP | claimed |
| WO-2015123408-A1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | INCYTE CORPORATION (US) | 2015-08-20 | — | — | WO | claimed |