Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6632132 | 0.77 | ALDH1A1 (0.36) | ALDH1A1MAPTTSHRGFERCHRM2 | |
| SCHEMBL4592349 | 0.75 | CHRM2 (0.37) | ALDH1A1MAPTTSHRGFERCHRM2 | |
| SCHEMBL7079770 | 0.73 | L3MBTL1 (0.35) | ALDH1A1MAPTTSHRGFERHTT | |
| SCHEMBL4591961 | 0.72 | CHRM2 (0.38) | ALDH1A1DPP4PREPFAPMAPT | |
| SCHEMBL27671943 | 0.70 | POLB (0.46) | ALDH1A1MAPTTSHRGFERMEN1 | |
| SCHEMBL10782723 | 0.70 | L3MBTL1 (0.32) | — | |
| SCHEMBL4591978 | 0.70 | L3MBTL1 (0.34) | ALDH1A1MAPTCHRM2CHRM4CHRM5 | |
| SCHEMBL7083426 | 0.70 | POLB (0.34) | ALDH1A1MEN1KMT2A | |
| SCHEMBL4591965 | 0.68 | HPGD (0.43) | ALDH1A1DPP4TSHRCHRM2CHRM4 | |
| SCHEMBL27519379 | 0.68 | ALDH1A1 (0.30) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3105219-A1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | Incyte Corporation (US) | 2016-12-21 | — | — | EP | claimed |
| WO-2015123408-A1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | INCYTE CORPORATION (US) | 2015-08-20 | — | — | WO | claimed |