Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8680079 | 0.78 | MAPT (0.34) | — | |
| SCHEMBL6632132 | 0.77 | ALDH1A1 (0.36) | MEN1KMT2AALDH1A1 | |
| SCHEMBL4592349 | 0.75 | CHRM2 (0.37) | MEN1KMT2AALDH1A1 | |
| SCHEMBL6557601 | 0.74 | LMNA (0.31) | — | |
| SCHEMBL7079770 | 0.73 | L3MBTL1 (0.35) | ALDH1A1 | |
| SCHEMBL27519379 | 0.72 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL4591961 | 0.72 | CHRM2 (0.38) | MEN1KMT2AALDH1A1 | |
| SCHEMBL10782723 | 0.70 | L3MBTL1 (0.32) | — | |
| SCHEMBL17010753 | 0.70 | ALDH1A1 (0.36) | MEN1KMT2AALDH1A1 | |
| SCHEMBL4591978 | 0.70 | L3MBTL1 (0.34) | POLBMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0897913-B1 | 4-carboxamido piperidine derivatives and their use as neurokinine antagonists | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| EP-0667858-B1 | 4-CARBOXOAMIDO PIPERIDINE DERIVATIVES, INTERMEDIATES AND USE AS NEUROKININ ANTAGONISTS | ZENECA LTD (GB) | 1999-08-25 | — | — | EP | disclosed |
| EP-0897913-A1 | 4-carboxamido piperidine derivatives and their use as neurokinine antagonists | ZENECA LIMITED (GB) | 1999-02-24 | — | — | EP | disclosed |