Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | MC3R | P41968 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.34 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.34 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.34 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.34 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.34 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17014183 | 0.82 | KDM4E (0.31) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL17014180 | 0.81 | CTNNB1 (0.42) | KDM4ENAPRTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL15658741 | 0.78 | KDM4E (0.45) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL17014181 | 0.77 | PLOD2 (0.46) | KDM4EHCAR2GAAALDH1A1KMT2A | |
| SCHEMBL17014178 | 0.76 | SMN1; SMN2 (0.42) | KDM4ENAPRTADORA3SMN1; SMN2GAA | |
| SCHEMBL15672500 | 0.74 | POLB (0.37) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL15294844 | 0.71 | ALDH1A1 (0.41) | KDM4ETSHRSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL15294846 | 0.70 | — | — | |
| SCHEMBL6281131 | 0.69 | KDM4E (0.52) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL15294845 | 0.68 | ALDH1A1 (0.45) | TSHRPOLBSMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9328124-B2 | BACE inhibitors | ELI LILLY AND COMPANY (US) | 2016-05-03 | — | — | US | disclosed |
| US-20150232483-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY | 2015-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232483-A1 | BACE INHIBITORS | BACE1, BACE2, APP | KDM4E 2782/4885NAPRT 2861/4885HCAR2 1599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.