Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.39 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.39 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15294844 | 0.87 | ALDH1A1 (0.41) | SMN1; SMN2PLOD2PLOD3PLOD1CYP1A2 | |
| SCHEMBL17014181 | 0.83 | PLOD2 (0.46) | PLOD2PLOD3PLOD1ALDH1A1GAA | |
| SCHEMBL17014177 | 0.76 | KDM4E (0.39) | SMN1; SMN2ALDH1A1GAANAPRTKDM4E | |
| SCHEMBL17014180 | 0.76 | CTNNB1 (0.42) | SMN1; SMN2ALDH1A1GAAHTTNAPRT | |
| SCHEMBL15294846 | 0.76 | — | — | |
| SCHEMBL15294845 | 0.76 | ALDH1A1 (0.45) | SMN1; SMN2CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL17005196 | 0.76 | ALDH1A1 (0.45) | SMN1; SMN2PLOD2PLOD3PLOD1CYP1A2 | |
| SCHEMBL15672497 | 0.71 | SMN1; SMN2 (0.38) | SMN1; SMN2PLOD2PLOD3PLOD1CYP1A2 | |
| SCHEMBL4962554 | 0.70 | SMN1; SMN2 (0.55) | SMN1; SMN2PLOD2PLOD3PLOD1CYP1A2 | |
| SCHEMBL27883074 | 0.69 | SMN1; SMN2 (0.50) | SMN1; SMN2PLOD2PLOD3PLOD1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9328124-B2 | BACE inhibitors | ELI LILLY AND COMPANY (US) | 2016-05-03 | — | — | US | disclosed |
| US-20150232483-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY | 2015-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232483-A1 | BACE INHIBITORS | BACE1, BACE2, APP | SMN1; SMN2 1298/4885PLOD2 4824/4885PLOD3 4426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.