Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.67 |
| ▸ | MMP2 | P08253 | 2/20 | 0.67 |
| ▸ | CA1 | P00915 | 1/20 | 0.67 |
| ▸ | MMP1 | P03956 | 1/20 | 0.67 |
| ▸ | MMP9 | P14780 | 1/20 | 0.67 |
| ▸ | MMP8 | P22894 | 1/20 | 0.67 |
| ▸ | MMP13 | P45452 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
| ▸ | CA5A | P35218 | 1/20 | 0.58 |
| ▸ | F2 | P00734 | 3/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.57 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.57 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL922350 | 0.87 | CA2 (0.71) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL13590904 | 0.83 | CA2 (0.75) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL6362188 | 0.82 | ALOX5 (0.69) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL1700168 | 0.80 | CA2 (0.71) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL4495753 | 0.80 | CA2 (0.71) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL12000920 | 0.80 | CA2 (1.00) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL2956545 | 0.80 | CA2 (0.71) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL17526270 | 0.79 | CA2 (0.66) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL5188248 | 0.79 | CA2 (0.65) | CA2MMP2CA1MMP1MMP9 | |
| SCHEMBL922441 | 0.79 | KMT2A (0.77) | CA2MMP2CA1MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576546-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbvie Inc. (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011149492-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-12-01 | — | — | WO | disclosed |