⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Chloride SCHEMBL11252480 | 0.91 | LMNA (0.44) | — | |
| SCHEMBL11250295 | 0.86 | NR1H2 (0.32) | — | |
| SCHEMBL9475224 | 0.76 | MAOA (0.64) | — | |
| SCHEMBL481976 | 0.76 | MAOA (0.64) | — | |
| SCHEMBL9476350 | 0.76 | MAOA (0.64) | — | |
| SCHEMBL162332 | 0.76 | LMNA (0.57) | — | |
| SCHEMBL16473648 | 0.76 | CYP1A2 (0.32) | — | |
| SCHEMBL11573148 | 0.75 | LMNA (0.47) | — | |
| SCHEMBL6546576 | 0.73 | MAOA (0.61) | — | |
| SCHEMBL6546581 | 0.73 | MAOA (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12024516-B2 | Tricyclic janus kinase 1 inhibitors, and compositions and methods thereof | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2024-07-02 | — | — | US | disclosed |
| US-12024516-B2 | Tricyclic janus kinase 1 inhibitors, and compositions and methods thereof | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2024-07-02 | — | — | US | disclosed |
| US-11858933-B2 | Tricyclic Janus kinase 1 inhibitors, and compositions and methods thereof | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2024-01-02 | — | — | US | disclosed |
| US-11858933-B2 | Tricyclic Janus kinase 1 inhibitors, and compositions and methods thereof | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2024-01-02 | — | — | US | disclosed |
| US-20230339950-A1 | TRICYCLIC JANUS KINASE 1 INHIBITORS, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2023-10-26 | — | — | US | disclosed |
| US-20230339950-A1 | TRICYCLIC JANUS KINASE 1 INHIBITORS, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2023-10-26 | — | — | US | disclosed |
| EP-3515880-B1 | METHODS AND COMPOSITIONS FOR SYNTHESIS OF ENCODED LIBRARIES | HITGEN INC (CN) | 2023-05-10 | — | — | EP | disclosed |
| US-20220009927-A1 | TRICYCLIC JANUS KINASE 1 INHIBITORS, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2022-01-13 | — | — | US | disclosed |
| CN-113880777-A | Preparation method and application of quinazolinone derivatives containing disulfide structures | 贵州大学 | 2022-01-04 | — | — | CN | disclosed |
| CN-113754595-A | Preparation method and application of 6-fluoroquinazoline derivatives containing disulfide structures | 贵州大学 | 2021-12-07 | — | — | CN | disclosed |
| US-4013774-A | INSECTICIDAL N-THIO-SUBSTITUTED CARBAMATES OF DIHYDROBENZOFURANOLS | CHEVRON RESEARCH COMPANY (US) | 1977-03-22 | — | — | US | disclosed |
| US-4003734-A | Substituted pyridinyloxy(thio)phenyl-acetamides, -ureas and urea derivatives and herbicidal compositions and methods containing said compounds | THE DOW CHEMICAL COMPANY (US) | 1977-01-18 | — | — | US | disclosed |
| US-4003733-A | HERBICIDES | THE DOW CHEMICAL COMPANY (US) | 1977-01-18 | — | — | US | disclosed |
| US-3997549-A | INSECTICIDE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1976-12-14 | — | — | US | disclosed |
| US-3988376-A | FUNGICIDES, ALGICIDES | CHEVRON RESEARCH COMPANY (US) | 1976-10-26 | — | — | US | disclosed |
| US-3984481-A | ALGICIDES AND FUNGICIDES | CHEVRON RESEARCH COMPANY (US) | 1976-10-05 | — | — | US | disclosed |
| US-3975427-A | Method for preparation of (d1)-13-substituted sulfinyl-prostaglandin-like compounds | SYNTEX (U.S.A.) INC. (US) | 1976-08-17 | — | — | US | disclosed |
| US-3970685-A | (DL)-13-Substituted sulfinyl-prostaglandin-like compounds | SYNTEX (U.S.A.) INC. (US) | 1976-07-20 | — | — | US | disclosed |
| US-3954997-A | MITICIDES, INSECTICIDES | THE UPJOHN COMPANY (US) | 1976-05-04 | — | — | US | disclosed |
| US-3931201-A | HERBICIDE | THE DOW CHEMICAL COMPANY (US) | 1976-01-06 | — | — | US | disclosed |