Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ADK | P55263 | 3/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591881 | 0.85 | MAPT (0.45) | MAPTPDGFRBKITKDM4EALDH1A1 | |
| SCHEMBL2827765 | 0.77 | FYN (0.56) | FYNPDGFRBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1701229 | 0.76 | PDPK1 (0.40) | FYNMAPTPDGFRBKITKDM4E | |
| SCHEMBL624711 | 0.75 | MEN1 (0.45) | MAPTKDM4EALDH1A1ALPLHPGD | |
| SCHEMBL8684518 | 0.70 | ILK (0.50) | MAPTKDM4EALDH1A1HSD17B10POLB | |
| SCHEMBL5499265 | 0.67 | CYP3A4 (0.52) | FYNMAPTPDGFRBKDM4EALDH1A1 | |
| SCHEMBL14088054 | 0.66 | CYP2C9 (0.55) | MAPTPDGFRBKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL15312178 | 0.65 | PDGFRB (0.70) | PDGFRBKITKDRCDK2CHEK1 | |
| SCHEMBL5210609 | 0.65 | SMN1; SMN2 (0.49) | MAPTKDM4EALDH1A1ALPLHPGD | |
| SCHEMBL1701249 | 0.65 | KDM4E (0.41) | MAPTKDM4EALDH1A1ALPLHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563776-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011139489-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2011-11-10 | — | — | WO | disclosed |