Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19291545 | 0.84 | CES2 (0.35) | CES2CES1HDAC3HDAC1HDAC2 | |
| SCHEMBL12282873 | 0.81 | SMN1; SMN2 (0.32) | PLA2G2APLA2G5FFAR3SMN1; SMN2ALDH1A1 | |
| SCHEMBL14942955 | 0.81 | SMN1; SMN2 (0.32) | PLA2G2APLA2G5FFAR3SMN1; SMN2ALDH1A1 | |
| SCHEMBL10140506 | 0.81 | SMN1; SMN2 (0.32) | PLA2G2APLA2G5FFAR3SMN1; SMN2ALDH1A1 | |
| SCHEMBL19364692 | 0.75 | PLA2G2A (0.37) | PLA2G2APLA2G5HDAC3HDAC1HDAC2 | |
| SCHEMBL19364746 | 0.75 | PLA2G2A (0.37) | PLA2G2APLA2G5HDAC3HDAC1HDAC2 | |
| SCHEMBL19485881 | 0.75 | PLA2G2A (0.37) | PLA2G2APLA2G5HDAC3HDAC1HDAC2 | |
| SCHEMBL17828424 | 0.74 | DPP4 (0.34) | DPP4 | |
| SCHEMBL20403663 | 0.74 | DPP4 (0.31) | DPP4 | |
| SCHEMBL23371499 | 0.74 | KISS1R (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015123679-A1 | HYDROPHILIC ANTIBODY-DRUG CONJUGATES | SEATTLE GENETICS, INC. (US) | 2015-08-20 | — | — | WO | disclosed |