Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | MITF | O75030 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.61 |
| ▸ | AXL | P30530 | 1/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28573902 | 0.83 | ALDH1A1 (0.71) | ALDH1A1KMT2AMKNK2SMN1; SMN2MKNK1 | |
| SCHEMBL28757721 | 0.82 | KMT2A (0.47) | ALDH1A1KMT2AMKNK2SMN1; SMN2MKNK1 | |
| SCHEMBL28587883 | 0.81 | ALDH1A1 (0.62) | ALDH1A1KMT2AMKNK2SMN1; SMN2MKNK1 | |
| SCHEMBL30512083 | 0.81 | ALDH1A1 (0.62) | ALDH1A1KMT2AMKNK2SMN1; SMN2MKNK1 | |
| SCHEMBL1662946 | 0.80 | SMN1; SMN2 (1.00) | ALDH1A1KMT2AMKNK2SMN1; SMN2MKNK1 | |
| SCHEMBL2303414 | 0.80 | ALDH1A1 (0.67) | ALDH1A1KMT2AMKNK2SMN1; SMN2MKNK1 | |
| SCHEMBL6956022 | 0.80 | ALDH1A1 (0.67) | ALDH1A1KMT2AMKNK2SMN1; SMN2MKNK1 | |
| SCHEMBL5630086 | 0.80 | MKNK1 (1.00) | ALDH1A1KMT2AMKNK2SMN1; SMN2MKNK1 | |
| SCHEMBL13815700 | 0.80 | KMT2A (1.00) | ALDH1A1KMT2AMKNK2SMN1; SMN2MKNK1 | |
| SCHEMBL28914376 | 0.80 | ALDH1A1 (0.67) | ALDH1A1KMT2AMKNK2SMN1; SMN2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116023380-B | Pyrazolopyrimidine derivative, and preparation method and application thereof | 沈阳药科大学 | 2024-01-23 | — | — | CN | disclosed |
| EP-3749647-B1 | N-(5-(PHENYL)-1H-PYRAZOL-3-YL)-1H-INDOL-5-AMINE DERIVATIVES AS TNIK INHIBITORS FOR THE TREATMENT OF CANCER | KOREA RES INST CHEMICAL TECH (KR) | 2023-09-27 | — | — | EP | disclosed |
| US-11767297-B2 | Compounds for inhibiting TNIK and medical uses thereof | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2023-09-26 | — | — | US | disclosed |
| US-11767297-B2 | Compounds for inhibiting TNIK and medical uses thereof | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2023-09-26 | — | — | US | disclosed |
| CN-112876482-B | Polysubstituted heterocyclic derivative, preparation method and medical application thereof | 中国药科大学 | 2023-07-28 | — | — | CN | disclosed |
| WO-2023071218-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 沈阳药科大学 | 2023-05-04 | — | — | WO | disclosed |
| CN-116023380-A | Pyrazolopyrimidine derivative, and preparation method and application thereof | 沈阳药科大学 | 2023-04-28 | — | — | CN | disclosed |
| US-20230039679-A1 | COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF | INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) | 2023-02-09 | — | — | US | disclosed |
| CN-112876482-A | Polysubstituted heterocyclic derivative, preparation method and medical application thereof | 中国药科大学 | 2021-06-01 | — | — | CN | disclosed |
| US-20210047300-A1 | HETERO RING-FUSED PHENYL COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2021-02-18 | — | — | US | disclosed |
| WO-2010015655-A1 | CYCLOHEXYL AMIDE DERIVATIVES AND THEIR USE AS CRF-1 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2010-02-11 | — | — | WO | disclosed |
| US-5723481-A | ANTIULCER AGENTS AND 5-LIPOXYGENASE INHIBITORS | SANKYO COMPANY, LIMITED (JP) | 1998-03-03 | — | — | US | disclosed |
| US-5698576-A | POSSESS ANTI-ULCER AND 5-LIPOXYGENASE INHIBITORY ACTIVITIES | SANKYO COMPANY, LIMITED (JP) | 1997-12-16 | — | — | US | disclosed |
| US-5665752-A | LIPOXYGENASE INHIBITORS | SANKYO COMPANY, LIMITED (JP) | 1997-09-09 | — | — | US | disclosed |
| CN-1034333-C | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | SANKYO CO (JP) | 1997-03-26 | — | — | CN | disclosed |
| CN-1032207-C | Imidazopyrazole derivatives useful as analgesics and anti-inflammatory agents | SANKYO CO (JP) | 1996-07-03 | — | — | CN | disclosed |
| US-5354768-A | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | SANKYO COMPANY, LIMITED (JP) | 1994-10-11 | — | — | US | disclosed |
| EP-0353047-B1 | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | SANKYO CO (JP) | 1994-10-05 | — | — | EP | disclosed |
| US-5232939-A | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | SANKYO COMPANY LIMITED (JP) | 1993-08-03 | — | — | US | disclosed |
| EP-0353047-A2 | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | Sankyo Company Limited (JP) | 1990-01-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11767297-B2 | Compounds for inhibiting TNIK and medical uses thereof | TNNI3K, TNK1, TNIK | ALDH1A1 4519/4885KMT2A 2586/4885MKNK2 213/4885 |
| US-20210047300-A1 | HETERO RING-FUSED PHENYL COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF | TNNI3K, TNK1, TNIK | ALDH1A1 4644/4885KMT2A 2261/4885MKNK2 223/4885 |
| US-20230039679-A1 | COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF | TNNI3K, TNK1, TNIK | ALDH1A1 4519/4885KMT2A 2586/4885MKNK2 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.