Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.67 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | MITF | O75030 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | STAT1 | P42224 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL330565 | 0.96 | ALDH1A1 (0.66) | ALDH1A1KMT2ASMN1; SMN2MKNK1MKNK2 | |
| SCHEMBL14190747 | 0.84 | LTA4H (0.74) | ALDH1A1KMT2ASMN1; SMN2MKNK1MKNK2 | |
| SCHEMBL28573902 | 0.83 | ALDH1A1 (0.71) | ALDH1A1KMT2ASMN1; SMN2MKNK1MKNK2 | |
| SCHEMBL5725231 | 0.83 | RAB9A (0.66) | ALDH1A1KMT2ASMN1; SMN2MKNK1MKNK2 | |
| SCHEMBL1702207 | 0.80 | ALDH1A1 (0.67) | ALDH1A1KMT2ASMN1; SMN2MKNK1MKNK2 | |
| SCHEMBL5630086 | 0.80 | MKNK1 (1.00) | ALDH1A1KMT2ASMN1; SMN2MKNK1MKNK2 | |
| SCHEMBL1662946 | 0.80 | SMN1; SMN2 (1.00) | ALDH1A1KMT2ASMN1; SMN2MKNK1MKNK2 | |
| SCHEMBL2303414 | 0.80 | ALDH1A1 (0.67) | ALDH1A1KMT2ASMN1; SMN2MKNK1MKNK2 | |
| SCHEMBL28914376 | 0.80 | ALDH1A1 (0.67) | ALDH1A1KMT2ASMN1; SMN2MKNK1MKNK2 | |
| SCHEMBL13815700 | 0.80 | KMT2A (1.00) | ALDH1A1KMT2ASMN1; SMN2MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0955293-B1 | UREA DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2003-03-19 | — | — | EP | disclosed |
| US-6043246-A | Urea derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2000-03-28 | — | — | US | disclosed |
| EP-0955293-A1 | NOVEL UREA DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-11-10 | — | — | EP | disclosed |