Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 6/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.36 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL395354 | 0.84 | ALDH1A1 (0.52) | SMN1; SMN2MEN1KMT2AL3MBTL1GALR3 | |
| SCHEMBL31634157 | 0.77 | ALDH1A1 (0.58) | SMN1; SMN2MEN1KMT2AL3MBTL1GALR3 | |
| SCHEMBL769557 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2AL3MBTL1GALR3 | |
| SCHEMBL376977 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2AL3MBTL1GALR3 | |
| SCHEMBL14210874 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2AL3MBTL1GALR3 | |
| SCHEMBL18708150 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2AL3MBTL1GALR3 | |
| SCHEMBL396875 | 0.73 | ALDH1A1 (0.49) | SMN1; SMN2MEN1KMT2AL3MBTL1GALR3 | |
| SCHEMBL376867 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2AL3MBTL1GALR3 | |
| SCHEMBL18467780 | 0.73 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2AL3MBTL1GALR3 | |
| SCHEMBL27754643 | 0.72 | GPR35 (0.51) | SMN1; SMN2MEN1KMT2AL3MBTL1GALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408750-B1 | PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2015-08-26 | — | — | EP | disclosed |