Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 8/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023025 | 0.91 | FGFR3 (0.59) | FGFR3TNIKLMNAKDM4EHTT | |
| SCHEMBL12678275 | 0.88 | FGFR3 (0.63) | FGFR3TNIKCYP2C19 | |
| SCHEMBL17023144 | 0.87 | FGFR3 (0.58) | FGFR3LMNAKDM4EFAAHHTT | |
| SCHEMBL17023046 | 0.87 | FGFR3 (0.42) | FGFR3 | |
| SCHEMBL17023121 | 0.84 | FGFR3 (0.40) | FGFR3LMNAKDM4EHTT | |
| SCHEMBL17023017 | 0.82 | FGFR3 (0.65) | FGFR3TNIKCYP2C19 | |
| SCHEMBL17023076 | 0.81 | FGFR3 (0.56) | FGFR3 | |
| SCHEMBL17023024 | 0.81 | FGFR3 (0.59) | FGFR3 | |
| SCHEMBL12678288 | 0.79 | FGFR3 (0.76) | FGFR3TNIK | |
| SCHEMBL17023072 | 0.78 | GAA (0.53) | TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |