Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 10/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | CIT | O14578 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12678296 | 0.88 | FGFR3 (0.74) | FGFR3MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL17023065 | 0.87 | FGFR3 (0.48) | FGFR3KDM4ELMNAHTTFAAH | |
| SCHEMBL17023025 | 0.85 | FGFR3 (0.59) | FGFR3KDM4ELMNAHTT | |
| SCHEMBL17023121 | 0.85 | FGFR3 (0.40) | FGFR3MAPTKMT2AALDH1A1MAPK1 | |
| SCHEMBL17023052 | 0.83 | FGFR3 (0.57) | FGFR3PTGER2 | |
| SCHEMBL17023046 | 0.82 | FGFR3 (0.42) | FGFR3 | |
| SCHEMBL17023076 | 0.79 | FGFR3 (0.56) | FGFR3 | |
| SCHEMBL17023024 | 0.78 | FGFR3 (0.59) | FGFR3 | |
| SCHEMBL17023018 | 0.77 | FGFR3 (0.45) | FGFR3MAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL17023016 | 0.76 | FGFR3 (0.49) | FGFR3MAPTKMT2AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |