Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | HCK | P08631 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023125 | 0.89 | L3MBTL1 (0.47) | GAANPSR1RAB9AMAPTTSHR | |
| SCHEMBL1127005 | 0.85 | MITF (0.55) | GAANPSR1MITFNPC1RAB9A | |
| SCHEMBL17023180 | 0.81 | NPC1 (0.49) | GAANPSR1MITFNPC1RAB9A | |
| SCHEMBL17023034 | 0.80 | FGFR3 (0.49) | GAANPSR1RAB9AHSP90AA1 | |
| SCHEMBL17023065 | 0.78 | FGFR3 (0.48) | TSHRKDM4E | |
| SCHEMBL17023017 | 0.78 | FGFR3 (0.65) | — | |
| SCHEMBL17023154 | 0.78 | FGFR3 (0.65) | GAANPSR1NPC1RAB9AMAPT | |
| SCHEMBL17023029 | 0.74 | FGFR3 (0.50) | NPC1RAB9AMAPTKMT2ATSHR | |
| SCHEMBL17023016 | 0.74 | FGFR3 (0.49) | GAANPSR1NPC1RAB9AMAPT | |
| SCHEMBL17023142 | 0.74 | FGFR3 (0.52) | NPSR1NPC1RAB9AMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |