Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 12/20 | 0.40 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | KDM4B | O94953 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12678313 | 0.87 | FGFR3 (0.53) | FGFR3ALK | |
| SCHEMBL17023046 | 0.87 | FGFR3 (0.42) | FGFR3GCK | |
| SCHEMBL17023144 | 0.85 | FGFR3 (0.58) | FGFR3KDM4ELMNAHTTALDH1A1 | |
| SCHEMBL17023065 | 0.84 | FGFR3 (0.48) | FGFR3KDM4ELMNAHTT | |
| SCHEMBL17023025 | 0.82 | FGFR3 (0.59) | FGFR3KDM4ELMNAHTT | |
| SCHEMBL17023076 | 0.82 | FGFR3 (0.56) | FGFR3 | |
| SCHEMBL17023024 | 0.81 | FGFR3 (0.59) | FGFR3 | |
| SCHEMBL17023075 | 0.81 | FGFR3 (0.54) | FGFR3 | |
| SCHEMBL17023049 | 0.78 | FGFR3 (0.62) | FGFR3 | |
| SCHEMBL17023146 | 0.76 | ADRA2A (0.34) | FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |