Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023074 | 0.91 | FGFR3 (0.59) | FGFR3LMNAMAPTCHRM1TSHR | |
| SCHEMBL1126965 | 0.88 | FGFR3 (0.60) | FGFR3LMNAMAPTSMN1; SMN2NPC1 | |
| SCHEMBL17023062 | 0.85 | FGFR3 (0.66) | FGFR3LMNAMAPTSMN1; SMN2NPC1 | |
| SCHEMBL17023029 | 0.79 | FGFR3 (0.50) | FGFR3LMNAMAPTSMN1; SMN2NPC1 | |
| SCHEMBL1126083 | 0.79 | FGFR3 (0.74) | FGFR3MAPTCHRM1TSHR | |
| SCHEMBL17023106 | 0.79 | HRH3 (0.47) | FGFR3SMN1; SMN2ABL1LCKBCR | |
| SCHEMBL17023181 | 0.78 | FGFR3 (0.59) | FGFR3LMNAPOLBJAK2ABL1 | |
| SCHEMBL17023180 | 0.77 | NPC1 (0.49) | FGFR3LMNAMAPTSMN1; SMN2NPC1 | |
| SCHEMBL17023176 | 0.76 | FGFR3 (0.80) | FGFR3JAK2ABL1INSRLCK | |
| SCHEMBL17023067 | 0.76 | FGFR3 (0.65) | FGFR3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |