Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023142 | 0.91 | FGFR3 (0.52) | NPC1MAPTRAB9ASMN1; SMN2FGFR3 | |
| SCHEMBL1126298 | 0.87 | FGFR3 (0.60) | NPC1MAPTRAB9ASMN1; SMN2FGFR3 | |
| SCHEMBL17023029 | 0.81 | FGFR3 (0.50) | NPC1MAPTRAB9ASMN1; SMN2FGFR3 | |
| SCHEMBL17023072 | 0.81 | GAA (0.53) | NPC1MAPTRAB9AESR2KMT2A | |
| SCHEMBL17023034 | 0.81 | FGFR3 (0.49) | RAB9ASMN1; SMN2FGFR3GAANPSR1 | |
| SCHEMBL12678269 | 0.78 | FGFR3 (0.63) | NPC1MAPTRAB9ASMN1; SMN2FGFR3 | |
| SCHEMBL17023109 | 0.77 | HRH3 (0.41) | FGFR3 | |
| SCHEMBL17023089 | 0.77 | FGFR3 (0.48) | NPC1MAPTRAB9ASMN1; SMN2FGFR3 | |
| SCHEMBL17023062 | 0.77 | FGFR3 (0.66) | NPC1MAPTRAB9ASMN1; SMN2FGFR3 | |
| SCHEMBL17023126 | 0.76 | FGFR3 (0.77) | FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |