Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12678295 | 0.87 | FGFR3 (0.63) | FGFR3L3MBTL1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17023125 | 0.86 | L3MBTL1 (0.47) | FGFR3L3MBTL1RAB9ASMN1; SMN2EGFR | |
| SCHEMBL17023034 | 0.84 | FGFR3 (0.49) | FGFR3L3MBTL1RAB9ASMN1; SMN2EGFR | |
| SCHEMBL17023116 | 0.84 | L3MBTL1 (0.48) | FGFR3L3MBTL1RAB9ASMN1; SMN2EGFR | |
| SCHEMBL17023015 | 0.81 | L3MBTL1 (0.54) | FGFR3L3MBTL1RAB9ASMN1; SMN2EGFR | |
| SCHEMBL17023052 | 0.79 | FGFR3 (0.57) | FGFR3 | |
| SCHEMBL4332010 | 0.77 | FGFR3 (0.53) | FGFR3L3MBTL1ALDH1A1HSD17B10ACVRL1 | |
| SCHEMBL17023144 | 0.76 | FGFR3 (0.58) | FGFR3ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL17023072 | 0.74 | GAA (0.53) | RAB9AALDH1A1MAPTKMT2AUSP2 | |
| SCHEMBL29739477 | 0.73 | GAA (0.68) | L3MBTL1RAB9ASMN1; SMN2EGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |