Phosphoric Acid

Phosphoric Acid

SCHEMBL1702344

O=P(O)(O)O.OP(O)(=S)S

nearest known ligand 0.38

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.36
SLC34A1 Q06495 1/20 0.33
KDM4E B2RXH2 1/20 0.31
MMP2 P08253 1/20 0.31
THRB P10828 1/20 0.31
MAPK1 P28482 1/20 0.31
HSD17B10 Q99714 1/20 0.31
FDPS P14324 1/20 0.31
BLM P54132 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25523 0.85
Phosphoramidic Acid SCHEMBL28814061 0.84 CA2 (0.31) CA2
Methyl Phosphonate SCHEMBL641732 0.84 CA2 (0.61) CA2
SCHEMBL16266082 0.82
Phosphoramidic Acid SCHEMBL7911731 0.81
SCHEMBL5934110 0.80
Hydrogen Sulfide SCHEMBL6899977 0.80
Phosphine SCHEMBL3457955 0.80
Potassium SCHEMBL11837016 0.80
SCHEMBL21044699 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 135 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4378531-A2 METHODS AND COMPOSITIONS FOR TREATING CANCERS USING ANTISENSE Thomas Jefferson University (US) 2024-06-05 EP disclosed
WO-2024077130-A1 METHODS AND COMPOSITIONS FOR TREATING BLADDER CANCER THOMAS JEFFERSON UNIVERSITY (US) 2024-04-11 WO disclosed
US-20240100078-A1 METHODS AND COMPOSITIONS FOR TREATING CANCERS USING ANTISENSE UNIV JEFFERSON (US) 2024-03-28 US disclosed
EP-3592841-B1 COMPOSITIONS FOR TREATING CANCERS USING ANTISENSE UNIV JEFFERSON (US) 2024-02-14 EP disclosed
WO-2023209220-A1 TARGETING MICRO RNA FOR TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF) Johann Wolfgang Goethe-Universität Frankfurt am Main (DE) 2023-11-02 WO disclosed
EP-4269586-A1 TARGETING MICRO RNA FOR TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF) Johann-Wolfgang-Goethe-Universität Frankfurt am Main (DE) 2023-11-01 EP disclosed
US-11801259-B2 Methods and compositions for treating cancers using antisense THOMAS JEFFERSON UNIVERSITY (US) 2023-10-31 US disclosed
US-20220195440-A1 METHODS FOR TREATING CANCERS USING ANTISENSE UNIV JEFFERSON (US) 2022-06-23 US disclosed
US-20220133800-A1 TREATMENT OF DISEASE BASED ON IMMUNE CELL SEQUENCING TGM LIFE SCIENCES LLC (US) 2022-05-05 US disclosed
CN-110747528-B Flame-retardant microcapsule and preparation method and application thereof 河北科技大学 2022-03-25 CN disclosed
EP-0734391-B1 PNA-DNA-PNA CHIMERIC MACROMOLECULES ISIS PHARMACEUTICALS INC (US) 2002-06-12 EP disclosed
EP-1201676-A2 PNA-DNA-PNA chimeric macromolecules ISIS PHARMACEUTICALS, INC. (US) 2002-05-02 EP disclosed
US-6277603-B1 PEPTIDE NUCLEIC ACID (PNA); THE DNA PORTION IS COMPOSED OF SUBUNITS OF AT LEAST ONE 2'-DEOXYNUCLEOTIDES; INCREASED NUCLEASE RESISTANCE; ACTIVATE RNASE H ENZYME, USE FOR IN VITRO MODIFICATION OF RNA ISIS PHARMACEUTICALS, INC. 2001-08-21 US disclosed
EP-0866070-A1 Derivatives of 7 deaza 2' deoxy guanosine 5' triphosphate, preparation and use thereof Amersham Pharmacia Biotech Inc (US) 1998-09-23 EP disclosed
US-5763370-A REACTION PRODUCT OF ANTIMONY DIAMYLDITHIOCARBAMATE AND MOLYBDENUM BIS/2-ETHYLHEXYL/DITHIOPHOSPHATE MOBIL OIL CORPORATION (US) 1998-06-09 US disclosed
EP-0734391-A4 PNA-DNA-PNA CHIMERIC MACROMOLECULES ISIS PHARMACEUTICALS INC (US) 1998-02-25 EP disclosed
US-5700922-A INCREASED NUCLEASE RESISTANCE, INCREASED BINDING AFFINITY TO COMPLEMENTARY STRANDS; MEDICAL DIAGNOSIS, THERAPY ISIS PHARMACEUTICALS, INC. (US) 1997-12-23 US disclosed
EP-0734391-A1 PNA-DNA-PNA CHIMERIC MACROMOLECULES ISIS PHARMACEUTICALS, INC. (US) 1996-10-02 EP disclosed
WO-1996024558-A1 METHOD AND APPARATUS FOR THERMAL DECOMPOSITION AND SEPARATION OF COMPONENTS WITHIN AN AQUEOUS STREAM HPR CORPORATION (US) 1996-08-15 WO disclosed
WO-1995014706-A1 PNA-DNA-PNA CHIMERIC MACROMOLECULES ISIS PHARMACEUTICALS, INC. (US) 1995-06-01 WO disclosed