Phenylalanine

Phenylalanine

SCHEMBL17023916

N.N[C@@H](Cc1ccccc1)C(=O)O.O=C(O)/C=C/c1ccccc1

nearest known ligand 0.67

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 4/20 0.67
PKM P14618 2/20 0.67
ALPI P09923 1/20 0.67
PTGS1 P23219 1/20 0.67
XIAP P98170 1/20 0.67
HDAC3 O15379 1/20 0.58
TNKS O95271 1/20 0.58
HDAC4 P56524 1/20 0.58
HDAC1 Q13547 1/20 0.58
HCAR2 Q8TDS4 1/20 0.58
HDAC7 Q8WUI4 1/20 0.58
HDAC2 Q92769 1/20 0.58
HDAC10 Q969S8 1/20 0.58
HDAC11 Q96DB2 1/20 0.58
HDAC8 Q9BY41 1/20 0.58
TNKS2 Q9H2K2 1/20 0.58
HDAC6 Q9UBN7 1/20 0.58
HDAC9 Q9UKV0 1/20 0.58
HDAC5 Q9UQL6 1/20 0.58
BACE1 P56817 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dl-Phenylalanine SCHEMBL8012735 0.98 SLC7A5 (0.69) SLC7A5PKMALPIPTGS1XIAP
Phenylalanine SCHEMBL8012741 0.98 SLC7A5 (0.69) SLC7A5PKMALPIPTGS1XIAP
Phenylalanine SCHEMBL8012746 0.98 SLC7A5 (0.69) SLC7A5PKMALPIPTGS1XIAP
Juarezic Acid SCHEMBL29070019 0.88 SLC7A5 (0.63) SLC7A5PKMALPIPTGS1XIAP
Chalcone SCHEMBL28237996 0.85 CYP1B1 (0.63) SLC7A5PKMALPIPTGS1XIAP
Tyrosine SCHEMBL17023915 0.85 SLC7A5 (0.69) SLC7A5PKMALPIPTGS1XIAP
SCHEMBL5332108 0.84 SLC7A5 (0.70) SLC7A5PKMALPIPTGS1XIAP
SCHEMBL31025610 0.84 SLC7A5 (0.70) SLC7A5PKMALPIPTGS1XIAP
Caffeic Acid SCHEMBL25430289 0.84 HSD17B10 (0.61) SLC7A5PKMALPIPTGS1XIAP
Caffeic Acid SCHEMBL25430292 0.84 HSD17B10 (0.61) SLC7A5PKMALPIPTGS1XIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10752921-B2 Enzymes and methods for styrene synthesis PHYTOGENE, INC. (US) 2020-08-25 US disclosed
US-10689672-B2 Vanillin synthase EVOLVA SA (CH) 2020-06-23 US disclosed
US-20180002726-A1 ENZYMES AND METHODS FOR STYRENE SYNTHESIS PHYTOGENE, INC. (US) 2018-01-04 US disclosed
US-20150337336-A1 ENZYMES AND METHODS FOR STYRENE SYNTHESIS PHYTOGENE, INC. 2015-11-26 US disclosed
US-20150267227-A1 Vanillin Synthase DANSTAR FERMENT AG (CH) 2015-09-24 US disclosed
US-20150240225-A1 BIOCHEMICAL STRESS RESISTANT MICROBIAL ORGANISM BIOCHEMTEX S.P.A. (IT) 2015-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150337336-A1 ENZYMES AND METHODS FOR STYRENE SYNTHESIS PSAT1, TKT, PAH SLC7A5 596/4885PKM 92/4885ALPI 911/4885
US-10752921-B2 Enzymes and methods for styrene synthesis PSAT1, HPD, TKT SLC7A5 693/4885PKM 139/4885ALPI 1056/4885
US-20180002726-A1 ENZYMES AND METHODS FOR STYRENE SYNTHESIS PSAT1, HPD, TKT SLC7A5 693/4885PKM 139/4885ALPI 1056/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.