Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.38 |
| ▸ | FABP7 | O15540 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361552 | 0.85 | — | — | |
| SCHEMBL26644664 | 0.83 | CD274 (0.32) | CD274 | |
| SCHEMBL26644661 | 0.83 | CD274 (0.32) | CD274 | |
| SCHEMBL26644663 | 0.83 | CD274 (0.32) | CD274 | |
| SCHEMBL7522377 | 0.81 | — | — | |
| SCHEMBL7522381 | 0.81 | — | — | |
| SCHEMBL7522379 | 0.81 | — | — | |
| SCHEMBL30896020 | 0.79 | EPHX2 (0.43) | EPHX2FABP5FABP7KMT2A | |
| SCHEMBL30792927 | 0.79 | EPHX2 (0.43) | EPHX2FABP5FABP7KMT2A | |
| SCHEMBL18154894 | 0.79 | EPHX2 (0.43) | EPHX2FABP5FABP7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240124525-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2024-04-18 | — | — | US | disclosed |
| US-20230357320-A1 | HELICAL STAPLED PEPTIDES AND USES THEREOF | PARABILIS MEDICINES, INC. | 2023-11-09 | — | — | US | disclosed |
| US-20220177522-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-06-09 | — | — | US | disclosed |
| EP-2920197-B1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | HARVARD COLLEGE (US) | 2021-03-17 | — | — | EP | disclosed |
| US-20180009847-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-01-11 | — | — | US | disclosed |
| US-9617309-B2 | Proline-locked stapled peptides and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-04-11 | — | — | US | disclosed |
| EP-2920197-A2 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | President and Fellows of Harvard College (US) | 2015-09-23 | — | — | EP | disclosed |
| US-20150239937-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357320-A1 | HELICAL STAPLED PEPTIDES AND USES THEREOF | ESRRB, ESR1, ESRRA | EPHX2 3867/4885CD274 821/4885FABP5 942/4885 |
| US-20150239937-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRAP1, PRR12, NPPA | EPHX2 2295/4885CD274 543/4885FABP5 1655/4885 |
| US-20240124525-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRAP1, PRR12, NPPA | EPHX2 2295/4885CD274 543/4885FABP5 1655/4885 |
| US-20180009847-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRAP1, PRR12, NPPA | EPHX2 2295/4885CD274 543/4885FABP5 1655/4885 |
| US-20220177522-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRAP1, PRR12, NPPA | EPHX2 2295/4885CD274 543/4885FABP5 1655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.