Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 8/20 | 0.38 |
| ▸ | RAB9A | P51151 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17416637 | 0.94 | PLK1 (0.39) | PLK1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL29684822 | 0.93 | PLK1 (0.39) | PLK1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL667456 | 0.93 | PLK1 (0.39) | PLK1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL18091873 | 0.89 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL667482 | 0.87 | PLK1 (0.37) | PLK1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL29684841 | 0.87 | PLK1 (0.37) | PLK1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL667440 | 0.87 | PLK1 (0.37) | PLK1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL29684483 | 0.87 | PLK1 (0.37) | PLK1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL9903268 | 0.83 | ALDH1A1 (0.38) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL29685124 | 0.81 | ABCB1 (0.38) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150240244-A1 | BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX | BIOPHARMA CREDIT PLC, AS COLLATERAL AGENT (GB) | 2015-08-27 | — | — | US | claimed |