Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29190477 | 0.80 | TMEM97 (0.41) | SIGMAR1ADRA2ATMEM97 | |
| SCHEMBL12622887 | 0.79 | TMEM97 (0.40) | SIGMAR1ADRA2AOPRM1OPRD1OPRK1 | |
| SCHEMBL2360287 | 0.78 | SIGMAR1 (0.52) | SIGMAR1ADRA2AOPRM1OPRD1 | |
| SCHEMBL3406036 | 0.78 | SIGMAR1 (0.37) | SIGMAR1ADRA2AOPRM1OPRD1OPRK1 | |
| SCHEMBL736557 | 0.78 | SIGMAR1 (0.52) | SIGMAR1ADRA2AOPRM1OPRD1 | |
| SCHEMBL24203981 | 0.76 | MEN1 (0.37) | SIGMAR1ADRA2AOPRM1OPRD1OPRK1 | |
| SCHEMBL11864088 | 0.76 | SIGMAR1 (0.54) | SIGMAR1ADRA2AOPRM1OPRD1OPRK1 | |
| SCHEMBL30376318 | 0.76 | MEN1 (0.37) | SIGMAR1ADRA2AOPRM1OPRD1OPRK1 | |
| SCHEMBL11401467 | 0.74 | TMEM97 (0.47) | SIGMAR1ADRA2AOPRM1TMEM97 | |
| SCHEMBL11401469 | 0.74 | TMEM97 (0.47) | SIGMAR1ADRA2AOPRM1TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107916-A1 | SPIRO-OXAZOLONES | F. Hoffmann-La Roche AG (CH) | 2016-12-28 | — | — | EP | disclosed |
| WO-2015124541-A1 | SPIRO-OXAZOLONES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-08-27 | — | — | WO | disclosed |