Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1703046 | 0.85 | FFAR4 (0.32) | FFAR4 | |
| SCHEMBL1703089 | 0.84 | CYP46A1 (0.33) | FFAR4 | |
| SCHEMBL12469952 | 0.81 | USP30 (0.32) | — | |
| SCHEMBL1702843 | 0.80 | AR (0.40) | HDAC8PTPN1HDAC3HDAC1HDAC2 | |
| SCHEMBL1702839 | 0.80 | AR (0.40) | HDAC8PTPN1HDAC3HDAC1HDAC2 | |
| SCHEMBL1702996 | 0.75 | AR (0.42) | HDAC8PTPN1HDAC3HDAC1HDAC2 | |
| SCHEMBL1702993 | 0.75 | AR (0.42) | HDAC8PTPN1HDAC3HDAC1HDAC2 | |
| SCHEMBL991893 | 0.67 | CYP46A1 (0.35) | — | |
| SCHEMBL1703049 | 0.64 | AR (0.42) | FFAR4 | |
| SCHEMBL1703045 | 0.64 | AR (0.42) | FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627627-B1 | PROCESS FOR THE SYNTHESIS OF CHIRAL PROPARGYLIC ALCOHOLS | BRISTOL MYERS SQUIBB CO (US) | 2017-08-09 | — | — | EP | disclosed |
| EP-2627643-B1 | PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES | BRISTOL MYERS SQUIBB CO (US) | 2016-11-23 | — | — | EP | disclosed |
| US-20160326101-A1 | Process for the Synthesis of Chiral Propargylic Alcohols | BRISTOL MYERS SQUIBB CO (US) | 2016-11-10 | — | — | US | disclosed |
| US-8969550-B2 | Process for the synthesis of cyclic carbamates | LONZA LTD. (CH) | 2015-03-03 | — | — | US | disclosed |
| US-8957204-B2 | Process for the synthesis of cyclic carbamates | LONZA LTD. (CH) | 2015-02-17 | — | — | US | disclosed |
| EP-2627642-B1 | PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES | LONZA AG (CH) | 2014-12-24 | — | — | EP | disclosed |
| US-20130324763-A1 | PROCESS FOR THE SYNTHESIS OF CHIRAL PROPARGYLIC ALCOHOLS | LONZA LTD (CH) | 2013-12-05 | — | — | US | disclosed |
| US-20130217875-A1 | PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES | LONZA LTD (CH) | 2013-08-22 | — | — | US | disclosed |
| US-20130211077-A1 | PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES | LONZA LTD (CH) | 2013-08-15 | — | — | US | disclosed |
| EP-2447255-A1 | Process for the synthesis of cyclic carbamates | Lonza Ltd. (CH) | 2012-05-02 | — | — | EP | disclosed |
| EP-2447247-A1 | Process for the synthesis of chiral propargylic alcohols | Lonza Ltd. (CH) | 2012-05-02 | — | — | EP | disclosed |
| EP-2441759-A1 | Process for the synthesis of cyclic carbamates | Lonza Ltd. (CH) | 2012-04-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326101-A1 | Process for the Synthesis of Chiral Propargylic Alcohols | ADH1C, ADH1A, ADH5 | HDAC8 4697/4885PTPN1 4737/4885HDAC3 3670/4885 |
| US-20130217875-A1 | PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES | PLCG2, PLCG1, CPS1 | HDAC8 3952/4885PTPN1 3345/4885HDAC3 3751/4885 |
| US-20130324763-A1 | PROCESS FOR THE SYNTHESIS OF CHIRAL PROPARGYLIC ALCOHOLS | ADH1C, ADH1A, ADH5 | HDAC8 4697/4885PTPN1 4737/4885HDAC3 3670/4885 |
| US-20130211077-A1 | PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES | PLCG2, PLCG1, PLCB1 | HDAC8 3057/4885PTPN1 2452/4885HDAC3 3971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.