Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | VEGFA | P15692 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17028827 | 0.91 | MEN1 (0.39) | FAAHALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL17028837 | 0.87 | ALDH1A1 (0.43) | L3MBTL1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL17028820 | 0.86 | ALDH1A1 (0.40) | ALDH1A1KDM4EPOLBVEGFAEGLN1 | |
| SCHEMBL17028826 | 0.86 | FAAH (0.46) | FAAHALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL17028830 | 0.85 | ALDH1A1 (0.46) | L3MBTL1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL17028846 | 0.85 | ALDH1A1 (0.37) | ALDH1A1KDM4ELMNASMN1; SMN2KMT2A | |
| SCHEMBL17028817 | 0.85 | MGLL (0.41) | L3MBTL1FAAHALDH1A1KDM4EKMT2A | |
| SCHEMBL17028841 | 0.84 | FAAH (0.42) | FAAHALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL17028844 | 0.83 | ALDH1A1 (0.52) | ALDH1A1KDM4ELMNASMN1; SMN2KMT2A | |
| SCHEMBL17028835 | 0.82 | ALDH1A1 (0.43) | FAAHALDH1A1KDM4ELMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107542-A1 | PROCESS FOR PREPARING N-BENZYL-3-HYDROXY-4-SUBSTITUTED-PYRIDIN-2-(1H)-ONES | Aerpio Therapeutics, Inc. (US) | 2016-12-28 | — | — | EP | disclosed |
| WO-2015126860-A1 | PROCESS FOR PREPARING N-BENZYL-3-HYDROXY-4-SUBSTITUTED-PYRIDIN-2-(1H)-ONES | AERPIO THERAPEUTICS, INC. (US) | 2015-08-27 | — | — | WO | disclosed |