Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.38 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.36 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | PLAU | P00749 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1558099 | 0.92 | SIRT6 (0.40) | ALOX15BMPR1AACVRL1ACVR1MAP3K7 | |
| SCHEMBL27033461 | 0.87 | F2 (0.35) | KDM5AGAAMAP3K7TAB1SIRT6 | |
| SCHEMBL15244435 | 0.87 | MEN1 (0.39) | ALOX15BMPR1AACVRL1ACVR1SIRT6 | |
| SCHEMBL216558 | 0.85 | ALOX15 (0.50) | ALOX15KDM5ABMPR1AACVRL1ACVR1 | |
| SCHEMBL9952208 | 0.84 | ALDH1A1 (0.36) | ALOX15MAP3K7TAB1SIRT6F2 | |
| SCHEMBL31361661 | 0.84 | ALDH1A1 (0.36) | ALOX15MAP3K7TAB1SIRT6F2 | |
| Hydrochloric Acid SCHEMBL15145595 | 0.83 | ALOX15 (0.49) | ALOX15KDM5ABMPR1AACVRL1ACVR1 | |
| SCHEMBL23612198 | 0.82 | GSK3B (0.40) | KDM5AMAP3K7TAB1ALDH1A1L3MBTL1 | |
| SCHEMBL23612062 | 0.81 | GSK3B (0.34) | KDM5AGAAMAP3K7TAB1F2 | |
| SCHEMBL174612 | 0.80 | F2 (0.41) | GAAF2PLAUELANEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440548-A1 | 2- ( LH-PYRAZOL-4 -YLAMINO ) -PYRIMIDINE AS KINASE INHIBITORS | Abbott Laboratories (US) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010144468-A1 | 2- ( LH-PYRAZOL-4 -YLAMINO ) -PYRIMIDINE AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2010-12-16 | — | — | WO | disclosed |