Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | GAA | P10253 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CD44 | P16070 | 1/20 | 0.50 |
| ▸ | NQO2 | P16083 | 6/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1884944 | 0.87 | GAA (0.64) | ABL1KDM4EGAAALDH1A1HSD17B10 | |
| SCHEMBL23774898 | 0.86 | GAA (0.54) | ABL1KDM4EGAAALDH1A1HSD17B10 | |
| SCHEMBL7762378 | 0.85 | ABL1 (0.61) | ABL1KDM4EGAAALDH1A1HSD17B10 | |
| SCHEMBL16662001 | 0.85 | GAA (0.51) | ABL1KDM4EGAAALDH1A1MAPT | |
| SCHEMBL681252 | 0.85 | KDM4E (0.63) | ABL1KDM4EGAAALDH1A1HSD17B10 | |
| SCHEMBL18432300 | 0.83 | GAA (0.46) | ABL1KDM4EGAAALDH1A1HSD17B10 | |
| SCHEMBL2897750 | 0.83 | KDM4E (0.61) | ABL1KDM4EGAAALDH1A1HSD17B10 | |
| SCHEMBL15358099 | 0.83 | ALDH1A1 (0.51) | KDM4EGAAALDH1A1HSD17B10MAPT | |
| SCHEMBL11922587 | 0.82 | ABL1 (0.57) | ABL1KDM4EGAAALDH1A1HSD17B10 | |
| SCHEMBL2897626 | 0.81 | GAA (0.62) | ABL1KDM4EGAAALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129553-A1 | BCL-2 INHIBITORS | Eil Therapeutics, Inc. (US) | 2023-07-06 | — | — | WO | disclosed |
| WO-2022265974-A1 | AMINOHETEROCYCLE-SUBSTITUTED TRICYCLIC KRAS INHIBITORS | ERASCA, INC. (US) | 2022-12-22 | — | — | WO | disclosed |
| US-20180118757-A1 | SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC | 2018-05-03 | — | — | US | disclosed |
| US-9840516-B2 | Substituted quinazolines as inhibitors of KRAS G12C | ARAXES PHARMA LLC (US) | 2017-12-12 | — | — | US | disclosed |
| US-20150239900-A1 | INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC | 2015-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118757-A1 | SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C | KRAS, NRAS, HRAS | ABL1 82/4885KDM4E 3221/4885GAA 2356/4885 |
| US-20150239900-A1 | INHIBITORS OF KRAS G12C | KRAS, NRAS, HRAS | ABL1 216/4885KDM4E 3220/4885GAA 2064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.