Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10722269 | 0.84 | TDP1 (0.52) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL21202580 | 0.77 | GRIN2B (0.37) | KMT2AMEN1KDM4EALDH1A1TDP1 | |
| SCHEMBL29580418 | 0.76 | KDM4E (0.51) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL6390410 | 0.76 | KDM4E (0.51) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL20687542 | 0.74 | ALDH1A1 (0.43) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL2359406 | 0.72 | KDM4E (0.51) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL29834958 | 0.72 | KDM4E (0.51) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL28264383 | 0.72 | KDM4E (0.51) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL8861255 | 0.72 | ALDH1A1 (0.51) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL7898823 | 0.72 | KDM4E (0.56) | KMT2AMEN1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440528-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010142656-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-16 | — | — | WO | disclosed |