Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20703976 | 0.77 | DAO (0.35) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL29580418 | 0.76 | KDM4E (0.51) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL8861255 | 0.76 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL28264383 | 0.76 | KDM4E (0.51) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL7898823 | 0.76 | KDM4E (0.56) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL29834958 | 0.76 | KDM4E (0.51) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL6390410 | 0.76 | KDM4E (0.51) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL28014515 | 0.74 | RPS6KA5 (0.47) | KDM4EMAPT | |
| SCHEMBL30050771 | 0.73 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL10722269 | 0.73 | TDP1 (0.52) | KDM4EALDH1A1HPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0450039-A1 | DIHYDRO-1,2 OXO-2 QUINOXALINE DERIVATES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS. | FABRE PIERRE COSMETIQUE (FR) | 1991-10-09 | — | — | EP | claimed |
| EP-2352725-A1 | QUINOXALINE-BASED LXR MODULATORS | Wyeth LLC (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2010054229-A1 | QUINOXALINE-BASED LXR MODULATORS | WYETH LLC (US) | 2010-05-14 | — | — | WO | disclosed |