SCHEMBL1703338

SCHEMBL1703338

COc1cc2c(cc1Cl)C(=O)CCC2(C)C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRA P19793 1/20 0.38
MAPK10 P53779 4/20 0.36
MAPK9 P45984 2/20 0.36
MAPK14 Q16539 2/20 0.36
MAPK8 P45983 1/20 0.36
HPGD P15428 1/20 0.36
HTT P42858 1/20 0.36
MAPT P10636 3/20 0.36
ALDH1A1 P00352 2/20 0.36
HSP90AA1 P07900 1/20 0.36
PKM P14618 1/20 0.36
MAPK1 P28482 1/20 0.36
RAB9A P51151 1/20 0.36
CCR6 P51684 1/20 0.36
CACNA1B Q00975 1/20 0.36
APBA1 Q02410 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
APOBEC3G Q9HC16 1/20 0.36
KDM4E B2RXH2 1/20 0.36
PGR P06401 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6085981 0.84 GRIN2D (0.40) RXRAHPGDALDH1A1KDM4EPGR
SCHEMBL4518869 0.83 RXRA (0.39) RXRAHPGDALDH1A1MAPK1KDM4E
SCHEMBL6087071 0.80 MALT1 (0.40) RXRAHPGDALDH1A1KDM4E
SCHEMBL8595488 0.78 PGR (0.50) MAPK10HPGDMAPTALDH1A1HSP90AA1
SCHEMBL10324926 0.74 HTR2A (0.41) MAPK10MAPK9MAPK14MAPK8MAPT
SCHEMBL8310387 0.73 RXRA (0.36) RXRA
SCHEMBL1660034 0.72 MAPK10 (0.48) MAPK10MAPK9MAPK14MAPK8MAPT
SCHEMBL31288649 0.72 MAPK10 (0.48) MAPK10MAPK9MAPK14MAPK8MAPT
SCHEMBL1808153 0.72 KDM4E (0.49) HTTALDH1A1MAPK1KDM4EGAA
SCHEMBL2061344 0.72 KDM4E (0.45) HTTALDH1A1MAPK1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2441753-A1 TETRACYCLIC COMPOUND Chugai Seiyaku Kabushiki Kaisha (JP) 2012-04-18 EP disclosed