Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL301752 | 0.86 | CA1 (0.44) | PGRMAPTALDH1A1CA1CA2 | |
| SCHEMBL4233485 | 0.81 | ACHE (0.45) | PGRAKR1B1MAPTALDH1A1GAA | |
| SCHEMBL5397188 | 0.79 | PGR (0.43) | PGRALDH1A1CA1CA2CA7 | |
| SCHEMBL1703338 | 0.78 | RXRA (0.38) | PGRFTOMAPTALDH1A1MAPK1 | |
| SCHEMBL5400962 | 0.77 | ACHE (0.45) | PGRAKR1B1MAPTALDH1A1GAA | |
| SCHEMBL14428501 | 0.76 | TNFSF11 (0.55) | PGRMAPTMAPK1CA1CA2 | |
| SCHEMBL24524147 | 0.73 | CA1 (0.39) | FTOAKR1B1MAPTALDH1A1MAPK1 | |
| SCHEMBL6553226 | 0.73 | PDE4B (0.37) | PGRMAPTALDH1A1RAB9AGAA | |
| SCHEMBL6554850 | 0.73 | PDE4B (0.37) | PGRMAPTALDH1A1RAB9AGAA | |
| SCHEMBL14428500 | 0.72 | PDE4A (0.41) | PGRMAPTALDH1A1MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657426-B1 | Tricyclic pyrrole derivatives | HOFFMANN LA ROCHE (CH) | 1998-07-22 | — | — | EP | disclosed |
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0657426-A2 | Tricyclic pyrrole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |