SCHEMBL17033658

SCHEMBL17033658

c1ccc(-c2cccc(-c3nc(-c4cccc(-c5ccccn5)c4)nc(-n4c5ccccc5c5ccc6cc7c8ccccc8c8ccccc8n7c6c54)n3)c2)nc1

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 6/20 0.37
HTR1A P08908 1/20 0.34
HTR7 P34969 1/20 0.34
PIK3CA P42336 1/20 0.33
PIK3CB P42338 1/20 0.33
PIK3CG P48736 1/20 0.33
HRH3 Q9Y5N1 1/20 0.33
IRAK4 Q9NWZ3 1/20 0.32
METAP2 P50579 2/20 0.32
GRM5 P41594 1/20 0.32
NPY5R Q15761 1/20 0.32
DHFR P00374 1/20 0.31
KDM4E B2RXH2 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
KAT6A Q92794 1/20 0.31
MAPK14 Q16539 1/20 0.31
PRKDC P78527 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16067149 0.92 MCL1 (0.37) MCL1HTR1AHTR7PIK3CAPIK3CB
SCHEMBL17033653 0.92 MCL1 (0.36) MCL1IRAK4METAP2NPY5RKDM4E
SCHEMBL17033445 0.89 MCL1 (0.35) MCL1HTR1AHTR7PIK3CAPIK3CB
SCHEMBL17033555 0.88 MCL1 (0.34) MCL1HTR1AHTR7PIK3CAPIK3CB
SCHEMBL17033604 0.87 GP6 (0.33) KDM4E
SCHEMBL17033597 0.86 HTR1A (0.43) MCL1HTR1AHTR7HRH3IRAK4
SCHEMBL17033655 0.86 DHODH (0.37) MCL1IRAK4METAP2NPY5RMAPK14
SCHEMBL16067179 0.86 MCL1 (0.36) MCL1HTR1AHTR7PIK3CAPIK3CB
SCHEMBL12131831 0.85 MCL1 (0.41) MCL1HTR1AHTR7PIK3CAPIK3CB
SCHEMBL17033640 0.85 KDM4E (0.33) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015125986-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME 주식회사 두산 2015-08-27 WO disclosed