Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.67 |
| ▸ | NOS3 | P29474 | 5/20 | 0.50 |
| ▸ | NOS1 | P29475 | 5/20 | 0.50 |
| ▸ | NOS2 | P35228 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.38 |
| ▸ | HTR3B | O95264 | 5/20 | 0.38 |
| ▸ | HTR3A | P46098 | 5/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8932568 | 0.80 | PLG (0.58) | PLGNOS3NOS1NOS2POLB | |
| SCHEMBL164098 | 0.80 | PLG (1.00) | PLGNOS3NOS1NOS2POLB | |
| Hydrochloric Acid SCHEMBL11099753 | 0.78 | PLG (0.95) | PLGNOS3NOS1NOS2POLB | |
| Phenylthiourea SCHEMBL7030440 | 0.75 | HTR3E (0.64) | NOS3NOS1NOS2POLBHTR3E | |
| Phenylthiourea SCHEMBL1387784 | 0.75 | HTR3E (0.64) | NOS3NOS1NOS2POLBHTR3E | |
| SCHEMBL1703432 | 0.74 | HTR3E (0.71) | PLGNOS3NOS1NOS2POLB | |
| Phenylthiourea SCHEMBL1286888 | 0.73 | HTR3E (0.61) | NOS3NOS1NOS2POLBHTR3E | |
| Phenylthiourea SCHEMBL4752640 | 0.73 | HTR3E (0.61) | NOS3NOS1NOS2POLBHTR3E | |
| Iodide SCHEMBL3529244 | 0.71 | CA12 (0.62) | NOS3NOS1NOS2POLBMAPT | |
| SCHEMBL8123733 | 0.71 | UHRF1 (0.42) | PLGNOS3NOS1NOS2HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440527-A1 | PYRIDINYL DERIVATIVES AS INHIBITORS OF ENZYME NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE | Topo Target A/S (DK) | 2012-04-18 | — | — | EP | disclosed |
| WO-2011121055-A1 | PYRIDINYL DERIVATIVES COMPRISING A CYANOGUANIDINE OR SQUARIC ACID MOIETY | TOPOTARGET A/S (DK) | 2011-10-06 | — | — | WO | disclosed |
| WO-2010142735-A1 | PYRIDINYL DERIVATIVES AS INHIBITORS OF ENZYME NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE | TOPOTARGET A/S (DK) | 2010-12-16 | — | — | WO | disclosed |
| WO-2009086835-A1 | NOVEL CYANOGUANIDINES | TOPOTARGET A/S (DK) | 2009-07-16 | — | — | WO | disclosed |
| CN-1247570-C | Novel pyridyl cyanoguandine compounds | LEO PHARMA AS (DK) | 2006-03-29 | — | — | CN | disclosed |
| CN-1509283-A | novel pyridyl cyanoguanidine compounds | ������ҩ������˾ | 2004-06-30 | — | — | CN | disclosed |
| EP-1397355-A1 | PYRIDYL CYANOGUANIDINE COMPOUNDS | Leo Pharma A/S (DK) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002094813-A1 | NOVEL PYRIDYL CYANOGUANIDINE COMPOUNDS | LEO PHARMA A/S (DK) | 2002-11-28 | — | — | WO | disclosed |
| EP-0984936-A1 | CYANOGUANIDINES AS CELL PROLIFERATION INHIBITORS | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998054142-A1 | CYANOGUANIDINES AS CELL PROLIFERATION INHIBITORS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1998-12-03 | — | — | WO | disclosed |
| WO-1998054141-A1 | CYANOGUANIDINES AS CELL PROLIFERATION INHIBITORS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1998-12-03 | — | — | WO | disclosed |