Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19004027 | 1.00 | TSHR (0.31) | TSHR | |
| SCHEMBL20049752 | 0.92 | ALDH1A1 (0.35) | — | |
| SCHEMBL12555769 | 0.92 | ALDH1A1 (0.35) | — | |
| SCHEMBL12555791 | 0.92 | ALDH1A1 (0.35) | — | |
| SCHEMBL20049545 | 0.87 | ALDH1A1 (0.39) | TSHR | |
| SCHEMBL12555775 | 0.87 | ALDH1A1 (0.39) | TSHR | |
| SCHEMBL12555789 | 0.87 | ALDH1A1 (0.39) | TSHR | |
| SCHEMBL23098234 | 0.84 | TSHR (0.31) | TSHR | |
| SCHEMBL24500426 | 0.84 | ALDH1A1 (0.30) | — | |
| SCHEMBL17035914 | 0.82 | TSHR (0.32) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180009847-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-01-11 | — | — | US | disclosed |
| US-9617309-B2 | Proline-locked stapled peptides and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-04-11 | — | — | US | disclosed |
| US-20150239937-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150239937-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRAP1, PRR12, NPPA | TSHR 4464/4885 |
| US-20180009847-A1 | PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF | PRAP1, PRR12, NPPA | TSHR 4464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.