Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | BMP1 | P13497 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL893056 | 0.91 | HDAC1 (0.57) | HDAC1HDAC6HDAC8TARBP2ALDH1A1 | |
| SCHEMBL11509023 | 0.82 | ALDH1A1 (0.48) | HDAC1HDAC6HDAC8TARBP2ALDH1A1 | |
| SCHEMBL8341931 | 0.81 | TARBP2 (0.60) | TARBP2ALDH1A1RAB9AMAPTKDM4E | |
| SCHEMBL8825404 | 0.80 | ALDH1A1 (0.52) | HDAC1HDAC6HDAC8TARBP2ALDH1A1 | |
| SCHEMBL8825537 | 0.79 | CDC7 (0.51) | TARBP2ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL5958307 | 0.79 | TRPM8 (0.56) | RAB9AMAPTSMN1; SMN2NPC1KMT2A | |
| SCHEMBL3108887 | 0.79 | NPC1 (0.49) | ALDH1A1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL8825390 | 0.78 | ALDH1A1 (0.53) | HDAC1HDAC6HDAC8TARBP2ALDH1A1 | |
| SCHEMBL8825436 | 0.78 | NPC1 (0.52) | ALDH1A1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL8825172 | 0.77 | ALDH1A1 (0.75) | TARBP2ALDH1A1RAB9AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440550-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010142801-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2010-12-16 | — | — | WO | disclosed |