Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | BMP1 | P13497 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoyl Chloride SCHEMBL1703592 | 0.91 | HDAC1 (0.49) | HDAC1HDAC6HDAC8TARBP2ALDH1A1 | |
| SCHEMBL11509023 | 0.90 | ALDH1A1 (0.48) | HDAC1HDAC6HDAC8TARBP2ALDH1A1 | |
| SCHEMBL8825537 | 0.87 | CDC7 (0.51) | TARBP2ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL3108887 | 0.86 | NPC1 (0.49) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL8825390 | 0.86 | ALDH1A1 (0.53) | HDAC1HDAC6HDAC8TARBP2ALDH1A1 | |
| SCHEMBL8341931 | 0.86 | TARBP2 (0.60) | TARBP2ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL8825436 | 0.85 | NPC1 (0.52) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL8825404 | 0.85 | ALDH1A1 (0.52) | HDAC1HDAC6HDAC8TARBP2ALDH1A1 | |
| SCHEMBL8825172 | 0.85 | ALDH1A1 (0.75) | TARBP2ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL5958307 | 0.84 | TRPM8 (0.56) | SMN1; SMN2MAPTRAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3713934-B1 | OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS | UNIV DEGLI STUDI DI PALERMO (IT) | 2022-04-13 | — | — | EP | claimed |
| US-11203578-B2 | Oxadiazole derivatives for the treatment of genetic diseases due to nonsense mutations | UNIVERSITA'DEGLI STUDI DIPALERMO (IT) | 2021-12-21 | — | — | US | claimed |
| EP-4568666-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | Alexion Pharmaceuticals, Inc. (US) | 2025-06-18 | — | — | EP | disclosed |
| CN-119768164-A | Pharmaceutical compounds for treating complement-mediated disorders | 阿雷克森制药公司 | 2025-04-04 | — | — | CN | disclosed |
| WO-2024035686-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ALEXION PHARMACEUTICALS, INC. (US) | 2024-02-15 | — | — | WO | disclosed |
| US-11834452-B2 | CXCR7 antagonists | CHEMOCENTRYX, INC. (US) | 2023-12-05 | — | — | US | disclosed |
| US-11834452-B2 | CXCR7 antagonists | CHEMOCENTRYX, INC. (US) | 2023-12-05 | — | — | US | disclosed |
| US-20220127272-A1 | CXCR7 ANTAGONISTS | CHEMOCENTRYX, INC. | 2022-04-28 | — | — | US | disclosed |
| US-11203578-B2 | Oxadiazole derivatives for the treatment of genetic diseases due to nonsense mutations | UNIVERSITA'DEGLI STUDI DIPALERMO (IT) | 2021-12-21 | — | — | US | disclosed |
| US-11203578-B2 | Oxadiazole derivatives for the treatment of genetic diseases due to nonsense mutations | UNIVERSITA'DEGLI STUDI DIPALERMO (IT) | 2021-12-21 | — | — | US | disclosed |
| US-11059825-B2 | CXCR7 antagonists | CHEMOCENTRYX, INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-9169261-B2 | CXCR7 antagonists | CHEMOCENTRYX, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-20140154179-A1 | CXCR7 ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2014-06-05 | — | — | US | disclosed |
| WO-2014085490-A1 | CXCR7 ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2014-06-05 | — | — | WO | disclosed |
| US-20140154179-A1 | CXCR7 ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2014-06-05 | — | — | US | disclosed |
| US-20140066457-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | REMYND (BE) | 2014-03-06 | — | — | US | disclosed |
| US-8618138-B2 | Indole amide derivatives and related compounds for use in the treatment of neurodegenerative diseases | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2013-12-31 | — | — | US | disclosed |
| EP-2440550-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-04-18 | — | — | EP | disclosed |
| US-20120083475-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-04-05 | — | — | US | disclosed |
| WO-2010142801-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2010-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083475-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, MAPT, NLN | HDAC1 2284/4885HDAC6 109/4885HDAC8 1575/4885 |
| US-20140066457-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, MAPT, NLN | HDAC1 2216/4885HDAC6 108/4885HDAC8 1584/4885 |
| US-11203578-B2 | Oxadiazole derivatives for the treatment of genetic diseases due to nonsense mutations | UPF1, OXA1L, RNMT | HDAC1 1141/4885HDAC6 1352/4885HDAC8 1880/4885 |
| US-11059825-B2 | CXCR7 antagonists | CXCR1, CXCR5, CCR7 | HDAC1 1101/4885HDAC6 738/4885HDAC8 1812/4885 |
| US-11834452-B2 | CXCR7 antagonists | CXCR1, CXCR5, CCR7 | HDAC1 1101/4885HDAC6 738/4885HDAC8 1812/4885 |
| US-20140154179-A1 | CXCR7 ANTAGONISTS | CXCR1, CXCR5, CCR7 | HDAC1 1101/4885HDAC6 738/4885HDAC8 1812/4885 |
| US-20220127272-A1 | CXCR7 ANTAGONISTS | CXCR1, CXCR5, CCR7 | HDAC1 1101/4885HDAC6 738/4885HDAC8 1812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.