Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | ATM | Q13315 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | HCK | P08631 | 4/20 | 0.58 |
| ▸ | NR2C2 | P49116 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | MAP3K7 | O43318 | 6/20 | 0.56 |
| ▸ | MAP4K2 | Q12851 | 6/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.56 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RAD52 | P43351 | 1/20 | 0.56 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.55 |
| ▸ | FES | P07332 | 3/20 | 0.54 |
| ▸ | FER | P16591 | 3/20 | 0.54 |
| ▸ | BTK | Q06187 | 2/20 | 0.54 |
| ▸ | GCK | P35557 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10158099 | 0.90 | ABL1 (0.58) | MAPK1ATMHTTHCKNR2C2 | |
| SCHEMBL1703715 | 0.86 | DDR2 (0.54) | HCKABL1MAPK14MAP3K20EGFR | |
| SCHEMBL31620779 | 0.83 | MAPK14 (0.62) | MAPK1ATMHTTHCKNR2C2 | |
| SCHEMBL1696346 | 0.80 | KIT (0.78) | MAPK1ATMHTTHCKNR2C2 | |
| SCHEMBL13878758 | 0.80 | HTT (0.74) | MAPK1ATMHTTHCKABL1 | |
| SCHEMBL3389535 | 0.80 | HTT (0.71) | MAPK1ATMHTTHCKNR2C2 | |
| SCHEMBL31620857 | 0.79 | BRAF (0.69) | ABL1EGFRBRAF | |
| SCHEMBL1705565 | 0.79 | LCK (0.65) | ABL1MAPK14BRAFMAPTBTK | |
| SCHEMBL1280098 | 0.78 | RET (0.81) | HCKNR2C2ABL1MAP3K7MAP4K2 | |
| SCHEMBL2226481 | 0.78 | HTT (0.68) | MAPK1ATMHTTHCKNR2C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505784-B2 | Fused 2-aminothiazole compounds | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-11-29 | — | — | US | disclosed |
| US-20150094315-A1 | FUSED 2-AMINOTHIAZOLE COMPOUNDS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-04-02 | — | — | US | disclosed |
| US-8765747-B2 | Fused 2-aminothiazole compounds | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120088766-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2012-04-12 | — | — | US | disclosed |
| WO-2010144909-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2010-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088766-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USES | OAT, OTC, DLD | MAPK1 4819/4885ATM 1765/4885HTT 354/4885 |
| US-20150094315-A1 | FUSED 2-AMINOTHIAZOLE COMPOUNDS | GOT2, OAT, ABAT | MAPK1 4847/4885ATM 689/4885HTT 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.