Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19563503 | 0.82 | PDK2 (0.35) | PDK2PDK4 | |
| SCHEMBL9896310 | 0.78 | CSNK2A1 (0.38) | CSNK2A1PDK2PDK4 | |
| SCHEMBL10252220 | 0.70 | TDP1 (0.35) | CSNK2A1PDK2PDK4 | |
| SCHEMBL6826337 | 0.67 | KDM4E (0.50) | — | |
| SCHEMBL20039914 | 0.64 | KDR (0.32) | PDK2 | |
| SCHEMBL31219145 | 0.64 | KDM4E (0.39) | — | |
| SCHEMBL31218990 | 0.62 | KDM4E (0.35) | — | |
| SCHEMBL2265436 | 0.62 | ALDH1A1 (0.37) | — | |
| SCHEMBL10252579 | 0.61 | HTT (0.33) | — | |
| SCHEMBL3114591 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10202386-B2 | Pyrrolo[3,2-D]pyrimidine derivatives as inducers of human interferon | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2019-02-12 | — | — | US | disclosed |
| US-10202386-B2 | Pyrrolo[3,2-D]pyrimidine derivatives as inducers of human interferon | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2019-02-12 | — | — | US | disclosed |
| EP-3107915-B1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES AS INDUCERS OF HUMAN INTERFERON | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO 2) LTD (GB) | 2017-11-08 | — | — | EP | disclosed |
| EP-3107915-B1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES AS INDUCERS OF HUMAN INTERFERON | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO 2) LTD (GB) | 2017-11-08 | — | — | EP | disclosed |
| US-20170057963-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES AS INDUCERS OF HUMAN INTERFERON | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-02 | — | — | US | disclosed |
| US-20170057963-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES AS INDUCERS OF HUMAN INTERFERON | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-02 | — | — | US | disclosed |
| WO-2015124591-A1 | PYRROLO[3,2] PYRIMIDINE DERIVATIVES AS INDUCERS OF HUMAN INTERFERON | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202386-B2 | Pyrrolo[3,2-D]pyrimidine derivatives as inducers of human interferon | IFNG, IFNAR1, IRF3 | CSNK2A1 1308/4885PDK2 1562/4885PDK4 1707/4885 |
| US-20170057963-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES AS INDUCERS OF HUMAN INTERFERON | IFNG, IFNAR1, IRF3 | CSNK2A1 1308/4885PDK2 1562/4885PDK4 1707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.