Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13464819 | 0.72 | KDR (0.63) | KDR | |
| SCHEMBL15612876 | 0.72 | KDM4E (0.42) | — | |
| SCHEMBL19929814 | 0.69 | KDM4E (0.31) | — | |
| SCHEMBL20182173 | 0.68 | PDK2 (0.45) | PDK2KMO | |
| SCHEMBL19563503 | 0.65 | PDK2 (0.35) | PDK2 | |
| SCHEMBL1762904 | 0.64 | KMO (0.34) | KMO | |
| SCHEMBL17039464 | 0.64 | CSNK2A1 (0.44) | PDK2 | |
| SCHEMBL17175005 | 0.64 | REN (0.36) | — | |
| SCHEMBL3002433 | 0.64 | DPP4 (0.61) | — | |
| SCHEMBL17175006 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670244-B1 | BICYCLIC AND TRICYCLIC PYRIMIDINE TYROSINE KINASE INHIBITORS WITH ANTITUBULIN ACTIVITY AND METHODS OF TREATING A PATIENT | UNIV HOLY GHOST DUQUESNE (US) | 2018-04-11 | — | — | EP | disclosed |