Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.78 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.75 |
| ▸ | LTA4H | P09960 | 6/20 | 0.71 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.67 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.67 |
| ▸ | SPR | P35270 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | HTR1D | P28221 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17037429 | 0.93 | SIRT2 (0.74) | SIRT2TRPM8LTA4HPLA2G2APOLB | |
| SCHEMBL6923780 | 0.89 | MTNR1A (0.82) | SIRT2TRPM8LTA4HPLA2G2APOLB | |
| SCHEMBL18222539 | 0.88 | TRPM8 (0.75) | SIRT2TRPM8LTA4HPLA2G2APOLB | |
| SCHEMBL7723651 | 0.88 | TRPM8 (0.78) | SIRT2TRPM8LTA4HPLA2G2APOLB | |
| SCHEMBL2841954 | 0.87 | TRPM8 (0.75) | SIRT2TRPM8LTA4HPLA2G2APOLB | |
| SCHEMBL7731853 | 0.87 | TRPM8 (0.77) | SIRT2TRPM8LTA4HPLA2G2APOLB | |
| SCHEMBL2413555 | 0.84 | TRPM8 (0.81) | SIRT2TRPM8LTA4HPLA2G2APOLB | |
| SCHEMBL8206907 | 0.84 | TRPM8 (0.73) | SIRT2TRPM8LTA4HPLA2G2APOLB | |
| SCHEMBL9121394 | 0.84 | MTNR1A (0.71) | SIRT2TRPM8LTA4HPLA2G2APOLB | |
| SCHEMBL1771890 | 0.83 | MTNR1A (0.80) | POLBMTNR1AMTNR1BSPRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20150239866-A1 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS | MERCK CANADA INC. (CA) | 2015-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150239866-A1 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS | SYK, BTK, TYRO3 | SIRT2 2868/4885TRPM8 4743/4885LTA4H 927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.