Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.73 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.68 |
| ▸ | LTA4H | P09960 | 4/20 | 0.67 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.62 |
| ▸ | HTR1D | P28221 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7731853 | 0.97 | TRPM8 (0.77) | TRPM8SIRT2LTA4HPLA2G2APOLB | |
| SCHEMBL7723651 | 0.96 | TRPM8 (0.78) | TRPM8SIRT2LTA4HPLA2G2APOLB | |
| SCHEMBL19051463 | 0.87 | TRPM8 (0.68) | TRPM8SIRT2LTA4HPLA2G2APOLB | |
| SCHEMBL6923780 | 0.86 | MTNR1A (0.82) | TRPM8SIRT2LTA4HPLA2G2APOLB | |
| SCHEMBL17949536 | 0.85 | MTNR1A (0.69) | TRPM8MTNR1AMTNR1BHTR1D | |
| SCHEMBL17040352 | 0.84 | SIRT2 (0.78) | TRPM8SIRT2LTA4HPLA2G2APOLB | |
| SCHEMBL18222539 | 0.84 | TRPM8 (0.75) | TRPM8SIRT2LTA4HPLA2G2APOLB | |
| SCHEMBL17949517 | 0.83 | MTNR1A (0.65) | TRPM8POLBMTNR1AMTNR1BHTR1D | |
| SCHEMBL12299324 | 0.83 | TRPM8 (0.63) | TRPM8SIRT2LTA4HPLA2G2APOLB | |
| SCHEMBL9528302 | 0.83 | TRPM8 (0.67) | TRPM8SIRT2LTA4HPLA2G2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000012045-A2 | METHOD FOR TREATING NEURODEGENERATIVE DISORDERS | ST. ELIZABETH'S MEDICAL CENTER OF BOSTON, INC. (US) | 2000-03-09 | — | — | WO | disclosed |
| WO-1999023070-A1 | N-ACETYLSEROTONIN DERIVATIVES AND USES THEREOF | ST. ELIZABETH'S MEDICAL CENTER OF BOSTON, INC. (US) | 1999-05-14 | — | — | WO | disclosed |