Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.57 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17037447 | 0.90 | ALDH1A1 (0.65) | ALDH1A1GABRA5KDM4ETHRBMAPT | |
| SCHEMBL13870636 | 0.83 | ALDH1A1 (0.77) | ALDH1A1GABRA5KDM4ETHRBMAPT | |
| SCHEMBL9494566 | 0.81 | ALDH1A1 (0.66) | ALDH1A1GABRA5KDM4ETHRBMAPT | |
| SCHEMBL14438335 | 0.79 | ALDH1A1 (0.59) | ALDH1A1GABRA5KDM4ETHRBMAPT | |
| SCHEMBL10310317 | 0.78 | ALDH1A1 (0.63) | ALDH1A1GABRA5KDM4ETHRBMAPT | |
| SCHEMBL27495332 | 0.76 | ALDH1A1 (0.59) | ALDH1A1GABRA5KDM4EMAPTPLA2G1B | |
| SCHEMBL1777512 | 0.76 | GABRA5 (0.72) | GABRA5 | |
| SCHEMBL2926617 | 0.76 | GABRA5 (1.00) | GABRA5 | |
| SCHEMBL2219161 | 0.76 | ALDH1A1 (0.55) | ALDH1A1GABRA5KDM4ETHRBMAPT | |
| SCHEMBL13062073 | 0.75 | CA12 (0.54) | ALDH1A1GABRA5KDM4ETHRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20150239866-A1 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS | MERCK CANADA INC. (CA) | 2015-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150239866-A1 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS | SYK, BTK, TYRO3 | ALDH1A1 3298/4885GABRA5 2173/4885KDM4E 1537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.